POST-ACTIVITY SKIL 1. The E2F family of transcription factors is important in regulating the cell cycle and has a role in cancer. These DNA binding proteins have conserved helix-turn-helix motifs that interact with DNA (NOTE: The DNA is represented as a stick diagram, whereas the protein is represented as helical ribbons.) Consider the protein a helix indicated by the arrow. This helix is approximately 16 amino acids in length and runs along side the DNA. Suggest a sequence for this 16 amino acid helix and provide a justification for your answer. Picture from Meinhart, A. et al. J. Biol. Chem. 2003;278:48267-48274 (used by permission). DNA View this skill exercise as an opportunity to practice scientific argumentation. Therefore the justification will be the most important aspect of your answer.
POST-ACTIVITY SKIL 1. The E2F family of transcription factors is important in regulating the cell cycle and has a role in cancer. These DNA binding proteins have conserved helix-turn-helix motifs that interact with DNA (NOTE: The DNA is represented as a stick diagram, whereas the protein is represented as helical ribbons.) Consider the protein a helix indicated by the arrow. This helix is approximately 16 amino acids in length and runs along side the DNA. Suggest a sequence for this 16 amino acid helix and provide a justification for your answer. Picture from Meinhart, A. et al. J. Biol. Chem. 2003;278:48267-48274 (used by permission). DNA View this skill exercise as an opportunity to practice scientific argumentation. Therefore the justification will be the most important aspect of your answer.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question 1 please. Need help. Please explain for understanding.
Thank you
Transcribed Image Text:## Skill Exercises
### Post-Activity
1. **Transcription Factors and DNA Interaction**
- The E2F family of transcription factors plays a crucial role in regulating the cell cycle and has implications in cancer. These DNA binding proteins have conserved helix-turn-helix motifs that interact with DNA.
- **Diagram Explanation:** The diagram shows DNA as a stick diagram and the protein as helical ribbons. A protein helix, indicated by an arrow, has approximately 16 amino acids in length and runs along the DNA.
- **Assignment:** Suggest a sequence for this 16 amino acid helix and provide justification for your choice. Reference image from Meinhart, A. et al. _J. Biol. Chem._ 2003;278:48267-48274 (used with permission).
*Consider your answer as an exercise in scientific argumentation; the justification is key.*
2. **Water and Protein Folding**
- Describe how water contributes to the favorable free energy change that facilitates protein folding as a spontaneous process.
3. **Protein Solvent Interaction**
- If a protein were placed in a nonpolar solvent, would it have the same structure as it has in water? Justify your answer.
4. **Amino Acid Dissolution Entropy**
- Compare and contrast the entropy changes of the dissolution of phenylalanine and aspartate in water.
5. **Energy Graph and Thermodynamic Parameters**
- **Graph Explanation:** The graph illustrates energy information related to thermodynamic parameters in macromolecular interactions. The x-axis represents different parameters: ΔG, ΔH, and TΔS, and the y-axis shows energy in Joules per mole (J/mol).
- **Assignment:** Propose a type of interaction that matches these data.
*Contributors: Rodney Austin, Martina Federer, Tracey Murray, and Heather Tienson*
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