Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
can you please explain the answer for this
![**Title: Synthesis Pathway Selection**
**Objective:**
Identify the appropriate reagents necessary to complete the given chemical synthesis.
**Synthesis Reaction:**
This is a multi-step synthesis starting with two alkenes and resulting in a ketone and carboxylic acid product.
**Steps and Structure:**
1. **Reaction 1:** Combine two alkene compounds. The intermediates or specific process for this step is not provided.
2. **Reaction 2:** Convert the intermediate product from Reaction 1 into the desired compound featuring a ketone and a carboxylic acid.
**Reagent Options:**
- \(\text{HNO}_3/\text{H}_2\text{SO}_4\)
- \(\text{NaOH, H}_2\text{O}\)
- \(\text{H}_2/\text{Pt}\)
- \(\text{O}_3/\text{DMS}\)
- Grubb’s Catalyst
- \(\text{Br}_2/h\nu\)
- NBS
- \(\text{Br}_2/\text{DCM}\)
- \(\text{AlCl}_3/\text{Cl}_2\)
- LDA/DIPA
- \(\text{KMnO}_4\)
- \(\text{NaN}_3/\text{CH}_3\text{CN}\)
- \(\text{AlCl}_3/\text{CH}_3\text{Cl}\)
- \(\text{HBr}/\text{DCM}\)
- Heat
- \(\text{NaCN, DMF}\)
- \(\text{Br}_2/\text{H}_2\text{O}\)
- \(\text{HBr}/\text{H}_2\text{O}\)
- 1. Li 2. CuI
- \(\text{HBr}/\text{H}_2\text{O}_2\)
- \(\text{H}_2\text{O}\)
- \(\text{CH}_3\text{Br}\)
- \(\text{NaSH, DMSO}\)
- \(\text{H}_2/\text{Pd}\)
- \(\text{Cl}_2/h\nu\)
- \(\text{MeOH}\)
- \(\text{EtOH}\)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4830af55-84e9-44a3-a1a9-c9fad267ce9b%2F5051f8e1-38aa-4a8d-b475-558972b23b33%2Feewgorp_processed.png&w=3840&q=75)
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