Photoreactivation - Covalent bonds 5' Ġ Ċ Ġ Å ET Ġ ÀČ Ġ саст AA стас 3' 3' Thymine dimer distorts the DNA molecule. iil 5' 5' Ġ Ċ GÅŤİ Ġ ÅČ Ġ CG CTAACTGC 3' An enzyme uses visible light to break the covalent bond of the thymine dimer, restoring the DNA to its original state. 3' Excision repair - Covalent bonds 5' Ġ C G Å TEŤ ĠÅ C Ġ сасT AA стас 3' LLI TI 3' Thymine dimer distorts the DNA molecule. i l5' Cut Cut An enzyme removes the damaged section by cutting the DNA backbone on either side of the 5' 3' CG CTAA CTGC 3' 1 5' thymine dimer. 5' GC GATT GAC G CGCTAA CTGC !TT 3' The combined actions of DNA polymerase and DNA ligase fill in and seal the gap. FIGURE 8.12 Repair of Thymine Dimers In photoreactivation, an enzyme uses the energy of light to break the covalent bonds. In excision repair, the section containing the dimer is replaced. >

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter28: Dna Metabolism: Replication, Recombination, And Repair
Section: Chapter Questions
Problem 1P: Semiconservative or Conservative DNA Replication If 15N-Iabeled E. coli DNA has a density of 1.724...
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How is the mechanism of excision repair similar to that of mismatch repair?

Photoreactivation
- Covalent bonds
5'
Ġ Ċ Ġ Å ET Ġ ÀČ Ġ
саст AA стас
3'
3'
Thymine dimer distorts the
DNA molecule.
iil 5'
5'
Ġ Ċ GÅŤİ Ġ ÅČ Ġ
CG CTAACTGC
3'
An enzyme uses visible light to
break the covalent bond of the
thymine dimer, restoring the DNA
to its original state.
3'
Excision repair
- Covalent bonds
5'
Ġ C G Å TEŤ ĠÅ C Ġ
сасT AA стас
3' LLI TI
3'
Thymine dimer distorts the
DNA molecule.
i l5'
Cut
Cut
An enzyme removes the damaged
section by cutting the DNA
backbone on either side of the
5'
3'
CG CTAA CTGC
3'
1 5'
thymine dimer.
5'
GC GATT GAC G
CGCTAA CTGC
!TT 3'
The combined actions of DNA
polymerase and DNA ligase fill in
and seal the gap.
FIGURE 8.12 Repair of Thymine Dimers In photoreactivation,
an enzyme uses the energy of light to break the covalent bonds. In
excision repair, the section containing the dimer is replaced.
>
Transcribed Image Text:Photoreactivation - Covalent bonds 5' Ġ Ċ Ġ Å ET Ġ ÀČ Ġ саст AA стас 3' 3' Thymine dimer distorts the DNA molecule. iil 5' 5' Ġ Ċ GÅŤİ Ġ ÅČ Ġ CG CTAACTGC 3' An enzyme uses visible light to break the covalent bond of the thymine dimer, restoring the DNA to its original state. 3' Excision repair - Covalent bonds 5' Ġ C G Å TEŤ ĠÅ C Ġ сасT AA стас 3' LLI TI 3' Thymine dimer distorts the DNA molecule. i l5' Cut Cut An enzyme removes the damaged section by cutting the DNA backbone on either side of the 5' 3' CG CTAA CTGC 3' 1 5' thymine dimer. 5' GC GATT GAC G CGCTAA CTGC !TT 3' The combined actions of DNA polymerase and DNA ligase fill in and seal the gap. FIGURE 8.12 Repair of Thymine Dimers In photoreactivation, an enzyme uses the energy of light to break the covalent bonds. In excision repair, the section containing the dimer is replaced. >
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