Ph3P C4H9Lİ Br an intermediate

Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter31: Immunochemistry
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### Transcription and Explanation of Reaction Scheme

#### Reaction Overview

1. **Reactants:**
   - **1-Bromobutane** is the first reactant on the top left, denoted as \[ \text{C}_4\text{H}_9\text{Br} \].
   - **Triphenylphosphine (Ph\(_3\)P)** is shown as the first reagent in the arrow from 1-bromobutane.
   - **Organolithium reagent (C\(_4\)H\(_9\)Li)** is the second reagent shown on the top pathway.

2. **Cyclohexanone** is the reactant on the bottom left, depicted as a cyclohexane ring with a ketone functional group.

3. **Intermediate**:
   - The term "an intermediate" suggests that a compound forms during the reaction path before reaching the final product.

#### Reaction Pathways

- **Top Pathway**:
  - **1-Bromobutane** reacts with **triphenylphosphine (Ph\(_3\)P)**, which is typically involved in the formation of a phosphonium salt or ylide.
  - The formed ylide then reacts with **an organolithium reagent (C\(_4\)H\(_9\)Li)**, suggesting a potential Wittig or related reaction, which usually forms a new carbon-carbon double bond.

- **Bottom Pathway**:
  - **Cyclohexanone** participates in another part of the reaction sequence, potentially interacting with the intermediate formed from the top pathway to generate the final product.

#### Important Chemistry Concepts

- **Triphenylphosphine** is often used in the **Wittig reaction**, which is a method to convert aldehydes and ketones into alkenes.
- **Organolithium compounds** are strong bases and nucleophiles used in creating carbon-carbon bonds.
- **Cyclohexanone** is a cyclic ketone involved in various synthetic transformations, often targeting the carbonyl group.

This diagram represents a synthetic scheme combining these reagents and intermediates to produce a complex organic molecule through a multi-step reaction, likely involving the formation of new carbon-carbon bonds.
Transcribed Image Text:### Transcription and Explanation of Reaction Scheme #### Reaction Overview 1. **Reactants:** - **1-Bromobutane** is the first reactant on the top left, denoted as \[ \text{C}_4\text{H}_9\text{Br} \]. - **Triphenylphosphine (Ph\(_3\)P)** is shown as the first reagent in the arrow from 1-bromobutane. - **Organolithium reagent (C\(_4\)H\(_9\)Li)** is the second reagent shown on the top pathway. 2. **Cyclohexanone** is the reactant on the bottom left, depicted as a cyclohexane ring with a ketone functional group. 3. **Intermediate**: - The term "an intermediate" suggests that a compound forms during the reaction path before reaching the final product. #### Reaction Pathways - **Top Pathway**: - **1-Bromobutane** reacts with **triphenylphosphine (Ph\(_3\)P)**, which is typically involved in the formation of a phosphonium salt or ylide. - The formed ylide then reacts with **an organolithium reagent (C\(_4\)H\(_9\)Li)**, suggesting a potential Wittig or related reaction, which usually forms a new carbon-carbon double bond. - **Bottom Pathway**: - **Cyclohexanone** participates in another part of the reaction sequence, potentially interacting with the intermediate formed from the top pathway to generate the final product. #### Important Chemistry Concepts - **Triphenylphosphine** is often used in the **Wittig reaction**, which is a method to convert aldehydes and ketones into alkenes. - **Organolithium compounds** are strong bases and nucleophiles used in creating carbon-carbon bonds. - **Cyclohexanone** is a cyclic ketone involved in various synthetic transformations, often targeting the carbonyl group. This diagram represents a synthetic scheme combining these reagents and intermediates to produce a complex organic molecule through a multi-step reaction, likely involving the formation of new carbon-carbon bonds.
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