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Part 1. Experiment to determine the specific binding of [3H]-flunitrazepam as defined by three different competing ligands Total binding Non-specific binding Specific binding c.p.m. 120.67 Total binding c.p.m. 143.00 Total binding c.p.m. 138 c.p.m. 110.67 Diazepam c.p.m. 128.00 2416.00 Flunitrazepam Non-specific binding Specific binding c.p.m. 133.00 c.p.m. Midazolam c.p.m. 2393.67 Non-specific binding Specific binding c.p.m. 2398.67 % Specific binding 95.24310118 % Specific binding 94.36268068 % Specific binding 94.55978975 Saturation experiments using radioligand is one method of determining the affinity of a ligand to a drug target. What are other methods used in high-throughput screening (HTS) of compound libraries that do not use a radioligand?

Part 1. Experiment to determine the specific binding of [3H]-flunitrazepam as defined by three different competing ligands Total binding Non-specific binding Specific binding c.p.m. 120.67 Total binding c.p.m. 143.00 Total binding c.p.m. 138 c.p.m. 110.67 Diazepam c.p.m. 128.00 2416.00 Flunitrazepam Non-specific binding Specific binding c.p.m. 133.00 c.p.m. Midazolam c.p.m. 2393.67 Non-specific binding Specific binding c.p.m. 2398.67 % Specific binding 95.24310118 % Specific binding 94.36268068 % Specific binding 94.55978975 Saturation experiments using radioligand is one method of determining the affinity of a ligand to a drug target. What are other methods used in high-throughput screening (HTS) of compound libraries that do not use a radioligand?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A A Aa A ₂²AA. Total binding c.p.m. 143.00 Part 1. Experiment to determine the specific binding of [3H]-flunitrazepam as defined by three different competing ligands Total binding c.p.m. AE 138 Total binding Non-specific binding Specific binding c.p.m. 120.67 English (United Kingdom) ====✓ | B c.p.m. 110.67 V Diazepam c.p.m. 133.00 c.p.m. 128.00 Flunitrazepam 2416.00 Non-specific binding Specific binding | ==| A | ¶ c.p.m. Midazolam 2393.67 c.p.m. Non-specific binding Specific binding c.p.m. 2398.67 % Specific binding 95.24310118 % Specific binding 94.36268068 % Specific binding 94.55978975 Saturation experiments using radioligand is one method of determining the affinity of a ligand to a drug target. What are other methods used in high-throughput screening (HTS) of compound libraries that do not use a radioligand? A[ Styles St P Focus each strategy?
Transcribed Image Text:A A Aa A ₂²AA. Total binding c.p.m. 143.00 Part 1. Experiment to determine the specific binding of [3H]-flunitrazepam as defined by three different competing ligands Total binding c.p.m. AE 138 Total binding Non-specific binding Specific binding c.p.m. 120.67 English (United Kingdom) ====✓ | B c.p.m. 110.67 V Diazepam c.p.m. 133.00 c.p.m. 128.00 Flunitrazepam 2416.00 Non-specific binding Specific binding | ==| A | ¶ c.p.m. Midazolam 2393.67 c.p.m. Non-specific binding Specific binding c.p.m. 2398.67 % Specific binding 95.24310118 % Specific binding 94.36268068 % Specific binding 94.55978975 Saturation experiments using radioligand is one method of determining the affinity of a ligand to a drug target. What are other methods used in high-throughput screening (HTS) of compound libraries that do not use a radioligand? A[ Styles St P Focus each strategy?
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