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OPO,2- \OH HO myo-inositol-1-phosphate synthase OH 2-03PO HO "OH HO (1 ÕH a-D-glucose-6-phosphate myo-inositol-1-phosphate a. What is the absolute configuration (R or S) at C-2 of naturally occurring a-D-glucose-6-phosphate? b. Using any unambiguous notation, draw the enantiomer (mirror image) of myo- inositol-1-phosphate. Place your answer in the space provided here.

OPO,2- \OH HO myo-inositol-1-phosphate synthase OH 2-03PO HO "OH HO (1 ÕH a-D-glucose-6-phosphate myo-inositol-1-phosphate a. What is the absolute configuration (R or S) at C-2 of naturally occurring a-D-glucose-6-phosphate? b. Using any unambiguous notation, draw the enantiomer (mirror image) of myo- inositol-1-phosphate. Place your answer in the space provided here.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Myo-inositol, the most prominent naturally occurring form of inositols, is a carbocyclic polyol that plays an important role as the structural basis for a number of secondary messengers in eukaryotic cells. It is generated in vivo from the aldol cyclization of glucose-6-phosphate to myo-inositol-1-phosphate

**Transcription and Explanation for Educational Website** --- **Chemical Transformations and Stereochemistry:** The image illustrates a biochemical reaction facilitated by the enzyme **myo-inositol-1-phosphate synthase**. Two chemical structures are involved in this transformation: 1. **α-D-glucose-6-phosphate** on the left. 2. **myo-inositol-1-phosphate** on the right. The structures are depicted with their respective phosphate groups, hydroxyl groups, and carbon atom configurations. **Key Features:** - **α-D-glucose-6-phosphate:** Exhibits a ring structure common to glucose derivatives, with multiple hydroxyl (-OH) groups and a phosphate group (2^O3PO) attached at the sixth carbon. The chiral center at the second carbon (C-2) is of particular interest here. - **myo-inositol-1-phosphate:** A cyclic alcohol with a phosphate group attached. This molecule results from the enzyme-catalyzed conversion of α-D-glucose-6-phosphate. **Questions for Consideration:** a. **Absolute Configuration Analysis:** - The diagram prompts the identification of the absolute configuration (R or S) at the C-2 position of naturally occurring α-D-glucose-6-phosphate. b. **Enantiomer Drawing:** - The diagram requests the drawing of the enantiomer (mirror image) of myo-inositol-1-phosphate. The space provided next to this task implies the expectation for a detailed, accurate depiction using any unambiguous notation. --- **Graphs and Diagrams Explanation:** - The arrows between the two chemical structures indicate the two-way enzymatic conversion between α-D-glucose-6-phosphate and myo-inositol-1-phosphate. - The stereochemistry around each chiral center is marked using wedges and dashes to denote the three-dimensional orientation of attached groups. This image and accompanying questions are typical in studies focusing on metabolic pathways and the stereochemical implications of enzymatic processes.
Transcribed Image Text:**Transcription and Explanation for Educational Website** --- **Chemical Transformations and Stereochemistry:** The image illustrates a biochemical reaction facilitated by the enzyme **myo-inositol-1-phosphate synthase**. Two chemical structures are involved in this transformation: 1. **α-D-glucose-6-phosphate** on the left. 2. **myo-inositol-1-phosphate** on the right. The structures are depicted with their respective phosphate groups, hydroxyl groups, and carbon atom configurations. **Key Features:** - **α-D-glucose-6-phosphate:** Exhibits a ring structure common to glucose derivatives, with multiple hydroxyl (-OH) groups and a phosphate group (2^O3PO) attached at the sixth carbon. The chiral center at the second carbon (C-2) is of particular interest here. - **myo-inositol-1-phosphate:** A cyclic alcohol with a phosphate group attached. This molecule results from the enzyme-catalyzed conversion of α-D-glucose-6-phosphate. **Questions for Consideration:** a. **Absolute Configuration Analysis:** - The diagram prompts the identification of the absolute configuration (R or S) at the C-2 position of naturally occurring α-D-glucose-6-phosphate. b. **Enantiomer Drawing:** - The diagram requests the drawing of the enantiomer (mirror image) of myo-inositol-1-phosphate. The space provided next to this task implies the expectation for a detailed, accurate depiction using any unambiguous notation. --- **Graphs and Diagrams Explanation:** - The arrows between the two chemical structures indicate the two-way enzymatic conversion between α-D-glucose-6-phosphate and myo-inositol-1-phosphate. - The stereochemistry around each chiral center is marked using wedges and dashes to denote the three-dimensional orientation of attached groups. This image and accompanying questions are typical in studies focusing on metabolic pathways and the stereochemical implications of enzymatic processes.
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Absolute configuration is R. This can be calculated based on the CIP rule. Chemistry homework question answer, step 1, image 1

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