One way that metabolic pathways are mapped is by following carbons at a particular position in a molecule in what is known as isotope tracing. This can be done by synthesizing the compound with a radioactive carbon at a specific position in the molecule and then seeing which product(s) of a reaction contain that carbon atom. Through this, scientists can follow the path of that carbon and see which parts of the molecule are being chemically altered. 6. The citrate molecule drawn below has its third carbon starred (pink star). Draw the metabolites (intermediates) of all steps (one full turn) of the citric acid cycle (write the names of each enzyme over the arrows like what is shown below), starring this carbon after each step so that you can follow it through the entire pathway and see where it ends up after the final step of the citric acid cycle. (30 points) (Hint: the citrate molecule was placed in the top center of the page because you will want to draw the citric acid cycle as a loop that comes back around to the citrate molecule at the end via the citrate synthase enzyme). HS-CoA + H+ HQ COO citrate synthase -00C COO aconitase H₂O citrate

One way that metabolic pathways are mapped is by following carbons at a particular position in a molecule in what is known as isotope tracing. This can be done by synthesizing the compound with a radioactive carbon at a specific position in the molecule and then seeing which product(s) of a reaction contain that carbon atom. Through this, scientists can follow the path of that carbon and see which parts of the molecule are being chemically altered. 6. The citrate molecule drawn below has its third carbon starred (pink star). Draw the metabolites (intermediates) of all steps (one full turn) of the citric acid cycle (write the names of each enzyme over the arrows like what is shown below), starring this carbon after each step so that you can follow it through the entire pathway and see where it ends up after the final step of the citric acid cycle. (30 points) (Hint: the citrate molecule was placed in the top center of the page because you will want to draw the citric acid cycle as a loop that comes back around to the citrate molecule at the end via the citrate synthase enzyme). HS-CoA + H+ HQ COO citrate synthase -00C COO aconitase H₂O citrate

Chemistry & Chemical Reactivity

10th Edition

ISBN:9781337399074

Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Chapter24: Biochemistry

Section: Chapter Questions

Problem 34GQ: The first step of the metabolic process known as glycolysis is the conversion of glucose to glucose-...

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SOURCE: GENERAL, ORGANIC AND BIOLOGICAL CHEMISTRY BY Smith 4th Edition
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Carbonic anhydrase facilitates the dissolution of carbon dioxide gas into water by catalyzing its hydration. Is the catalyzed reaction efficient? By what criterion do you state that?
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