ola CH3 Ph- Primary amines add to aldehydes and ketones to give imines. Imines are formed in a reversible, acid-catalyzed process that begins with nucleophilic addition of the primary amine to the carbonyl group, followed by transfer of the proton to yield a neutral carbinolamine. Protonation of the hydroxyl group converts it into a good leaving group and an E1-like loss of water yields an iminium io Deprotonation yields the product imine and regenerates the acid catalyst. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions 07 →XT :OH₂ NHOH NH₂OH CH3 LOH or CH3 OH H-OH HN Ph CH3 H₂O за

ola CH3 Ph- Primary amines add to aldehydes and ketones to give imines. Imines are formed in a reversible, acid-catalyzed process that begins with nucleophilic addition of the primary amine to the carbonyl group, followed by transfer of the proton to yield a neutral carbinolamine. Protonation of the hydroxyl group converts it into a good leaving group and an E1-like loss of water yields an iminium io Deprotonation yields the product imine and regenerates the acid catalyst. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions 07 →XT :OH₂ NHOH NH₂OH CH3 LOH or CH3 OH H-OH HN Ph CH3 H₂O за

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

Propose a strategy for the given synthesis.
Provide a mechanism that accounts for the outcome of the following hydrolysis reaction. H3O+ ?
Of the compounds shown below, the one numbered enamine H CH3 на CH3CH₂CHCH₂CH₂ 1 When a ketone reacts with 1 mole of alcohol, the resultant product is classified as acetal Ohemiacetal acetal hemiketal CH₂ Ph CHỊCH CHCH CH 2 CH₁ CH₂ حمله CH₂CH₂C=CHCH₂ 3 What is the best choice of reagent to perform the following transformation? Ph is an CI
Arrow-pushing Instructions ^^C↔X™ Ph Ph CI Acid chlorides react with Grignard reagents to yield tertiary alcohols, two equivalents of Grignard reagent are required. The first equivalent reacts in a typical nucleophilic acyl substitution reaction to give a ketone. This ketone, however, is itself reactive in the Grignard reaction. Thus, the second equivalent adds to the ketone carbonyl carbon. Subsequent protonation yields the tertiary alcohol. Draw curved arrows to show the movement of electrons in this step of the mechanism. :O: CH3 1. 2 eq. CH3MgBr 2. H3O+ Submit Answer H3C-MgBr H3C CH3 X Try Another Version Ph 1 item attempt remaining OH Ph + :: MgBr -CH3 CH3
Fill in the boxes below with the appropriate reagents or structures. Each part includes a hydrolysis reaction, thus the boxes should contain two products (assume that the pH has been adjusted so that the products exist as neutrally charged species).
NMO2 ОН CH3 H3C CI N(CH2CH3)3 Dimethylaminopyridine (DMAP) is often used as a catalyst in esterification reactions. A basic solvent such as triethylamine is used to react with the liberated proton from the alcohol group. Draw curved arrows to show the movement of electrons in this step of the mechanism. Arrow-pushing Instructions :ö: :0: :O: :N- NME2 H3C- :N- NME2 H3C H. : N(CH,CH3)3 Previous Next O:
Following are two possible retrosynthetic analyses for the anticholinergic drug cycri- mine. Fill in the details of each potential synthesis. O: OH + H. Cycrimine (гасemic)
Protons on a carbon atom located adjacent to the carbonyl group generally absorb in the range of 1-2.5 ppm. Protons on a carbon atom located adjacent to an oxygen atom generally absorb in the range of 3.5-5 ppm. What is the structure of the ester from the Proton NMR spectrum?
When an α-hydroxy amide is treated with Br2 in aqueous NaOH under Hofmann rearrangement conditions, loss of CO2 occurs and a chain-shortened aldehyde is formed. The mechanism involves the following steps: Base abstracts an acidic amide proton, yielding amide anion 1; The amide anion reacts with bromine in an α-substitution reaction to give N-bromoamide 2. Abstraction of the remaining amide proton by base gives a resonance-stabilized bromoamide anion 3; Rearrangement occurs to yield isocyanate 4; Water adds to the isocyanate to yield carbamic acid 5; Elimination of CO2 yields carbinolamine 6; Following proton transfer, expulsion of ammonia yields the final product aldehyde. Write out the mechanism and then draw the structures of bromoamide anion 3 and amide anion 1.