Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Question
Draw a stepwise mechanism for the following reaction, a key step in the synthesis of vernakalant, a drug approved in Europe in 2010 for the treatment of atrial fibrillation. Pure B was separated from a mixture of diastereomers. Your mechanism must explain the trans stereochemistry of the two substituents on the six-membered ring.
![OCH3
OS02CH3
ОСНЗ
OCH3
Nat-o
OCH3
"оСн,
OCH3
one
step
vernakalant](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa24b12e6-b4bb-4cf2-9934-3ce352d0df18%2Feda5d9ac-6a62-4cb8-a97e-aa9f347b3ee6%2Fxrr70xl.png&w=3840&q=75)
Transcribed Image Text:OCH3
OS02CH3
ОСНЗ
OCH3
Nat-o
OCH3
"оСн,
OCH3
one
step
vernakalant
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