Chemistry for Engineering Students
3rd Edition
ISBN:9781285199023
Author:Lawrence S. Brown, Tom Holme
Publisher:Lawrence S. Brown, Tom Holme
Chapter1: Introduction To Chemistry
Section: Chapter Questions
Problem 1.82PAE: Use the web to research the elastic modulus and yield strength of carbon fiber composites. How do...
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Question
Draw a stepwise mechanism for the following reaction, a key step in the synthesis of vernakalant, a drug approved in Europe in 2010 for the treatment of atrial fibrillation. Pure B was separated from a mixture of diastereomers. Your mechanism must explain the trans stereochemistry of the two substituents on the six-membered ring.
Transcribed Image Text:OCH3
OS02CH3
ОСНЗ
OCH3
Nat-o
OCH3
"оСн,
OCH3
one
step
vernakalant
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