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- What are ketone bodies? How are they formed? What makes carboxylic acids acidic? Define the following terms and give examples of eacha) Analgesicb) Antipyretic(c) Which phase of cell growth is disrupted by antimetabolites? Explain how as folate methotrexate functions antagonist. antimaboliteswhat is the application of OCT in medicine?
- List two classes of compounds derived from arachidonic acid. Suggest some reasons for the amount of biomedical research devoted to these compounds.Which of the following describes where in the model chloramphenicol acts to interfere with the production of proteins from DNA?categorize the following into reversible or irreversible (competitive or non-competitive) inhibitors. No explanation is required, just list the name of the inhibitor. a) Penicillin b) Cyanide c) Aspirin d) Tipranavir
- Since cholesterol, Vitamin D, and the mammalian sex hormones are among this group of metabolites are they true secondary metabolites? What are the functions of steroids? How are sterols classified? How are the different categories justified?why is chymotrypsin inactive at high pH?Identify the following statements as true or false. If a statement is false, explain what is wrong with that statement a) Transition state analogs bind very tightly with the enzyme active site as they form covalent bonds with the active site b) Receptor desensitization happens upon prolonged exposure of receptors to both agonists and antagonists c) Dactinomycin and Doxorubicin are examples of drugs that bind with the major groove of DNA d) Mitomycin C forms interstrand crosslinking while cisplatin forms intrastrand crosslinking of DNA
- Why does Glutathione have a low bioavailability when applied topically?Consider the decapeptide angiotensin I.a. What products are formed when angiotensin I is treated with trypsin?b. What products are formed when angiotensin I is treated with chymotrypsin?c. Treatment of angiotensin I with ACE (the angiotensin-converting enzyme) cleaves only the amide bond with the carbonyl group derived from phenylalanine to afford two products. The larger polypeptide is angiotensin II, a hormone that narrows blood vessels and increases blood pressure. Give the amino acid sequence of angiotensin II using three-letter abbreviations. ACE inhibitors are drugs that lower blood pressure by inhibiting the ACE enzymeWhat is the mechanism of chymotrypsin catalysed by enzymes without cofactors?