n the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate 1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction. LOCH3 (H;C);C. LOCH3 (CH3);COH CH;COOH/H,SO4 H;CO H;CO `C(CH3)3 The primary difference between Friedel-Crafts EAS reactions and other EAS reactions
n the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate 1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction. LOCH3 (H;C);C. LOCH3 (CH3);COH CH;COOH/H,SO4 H;CO H;CO `C(CH3)3 The primary difference between Friedel-Crafts EAS reactions and other EAS reactions
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Outline a mechanism for the formation of the compound. Please use software to draw the reaction
![In the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate
1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction.
LOCH3
(H;C);C.
LOCH3
(CH3);COH
CH;COOH/H,SO4
H;CO
H;CO
`C(CH3)3
The primary difference between Friedel-Crafts EAS reactions and other EAS reactions
(i.e., nitration, halogenation, etc.) is that in a Friedel-Crafts reaction (alkylation or acylation), the
electrophile is a carbon atom (i.e., in this experiment it is a tert.-butyl carbocation). In many cases,
the Friedel-Crafts electrophile is generated using a chlorine-containing molecule (i.e., an acyl
[acid] chloride or an alkyl chloride) and an appropriate Lewis acid (i.e., AlCl3, BF3) catalyst
(examples are shown below):
Acyl halide
8-
+ AlCl3
.AICI3
R
R
`Cl
8+
+ AICI4
A 11u1 helido](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1bc59cb9-d57c-45f6-809f-14f736729ead%2Fce155a94-35ff-46b5-8a64-787678083141%2F4j9lucr_processed.png&w=3840&q=75)
Transcribed Image Text:In the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate
1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction.
LOCH3
(H;C);C.
LOCH3
(CH3);COH
CH;COOH/H,SO4
H;CO
H;CO
`C(CH3)3
The primary difference between Friedel-Crafts EAS reactions and other EAS reactions
(i.e., nitration, halogenation, etc.) is that in a Friedel-Crafts reaction (alkylation or acylation), the
electrophile is a carbon atom (i.e., in this experiment it is a tert.-butyl carbocation). In many cases,
the Friedel-Crafts electrophile is generated using a chlorine-containing molecule (i.e., an acyl
[acid] chloride or an alkyl chloride) and an appropriate Lewis acid (i.e., AlCl3, BF3) catalyst
(examples are shown below):
Acyl halide
8-
+ AlCl3
.AICI3
R
R
`Cl
8+
+ AICI4
A 11u1 helido
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