n the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate 1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction. LOCH3 (H;C);C. LOCH3 (CH3);COH CH;COOH/H,SO4 H;CO H;CO `C(CH3)3 The primary difference between Friedel-Crafts EAS reactions and other EAS reactions
n the current experiment, we will use a different electrophile (the tert.-butyl cation) to alkylate 1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction. LOCH3 (H;C);C. LOCH3 (CH3);COH CH;COOH/H,SO4 H;CO H;CO `C(CH3)3 The primary difference between Friedel-Crafts EAS reactions and other EAS reactions
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Outline a mechanism for the formation of the compound. Please use software to draw the reaction

Transcribed Image Text:In the current experiment, we will use a different electrophile (the tert-butyl cation) to alkylate 1,4-dimethoxybenzene. This is a Friedel-Crafts Alkylation reaction.
**Chemical Reaction:**
The experiment involves reacting 1,4-dimethoxybenzene with a tert-butyl cation in the presence of acetic acid (CH₃COOH) and sulfuric acid (H₂SO₄), resulting in an alkylated product. The structural formula of 1,4-dimethoxybenzene on the left shows two methoxy groups (-OCH₃) attached to a benzene ring. This is converted into a product where tert-butyl groups (C(CH₃)₃) are added to the benzene ring.
**Differences in Friedel-Crafts Reactions:**
The primary difference between Friedel-Crafts electrophilic aromatic substitution (EAS) reactions and other EAS reactions (such as nitration or halogenation) is the electrophile involved. In Friedel-Crafts reactions (alkylation or acylation), the electrophile is a carbon atom, such as the tert-butyl carbocation in this experiment. Friedel-Crafts electrophiles are typically generated using chlorine-containing molecules like acyl chloride or alkyl chloride and a suitable Lewis acid (such as AlCl₃ or BF₃).
**Diagrams:**
1. **Acyl Halide Reaction:**
- **Reactants:** Acyl chloride (RCOCl) and aluminum chloride (AlCl₃).
- **Mechanism:** The acyl chloride reacts with AlCl₃, forming a complex. The chlorine atom leaves, creating a positively charged acylium ion (RCO⁺) that serves as the active electrophile in the reaction.
The diagrams illustrate these reactions with structural chemical formulas, showing the transition from reactants to intermediates and products.
Expert Solution
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Step 1
Friedel crafts an alkylation reaction in which a benzene molecule replaces its Hydrogen atom with an alkyl group in the presence of acid.
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