Morphine and its O-methylated derivative codeine are among the most effective pain- killers known. However, they possess two serious drawbacks: they are addictive, and repeated use induces a tolerance to the drug. Many morphine analogs have been pre- pared in an effort to find drugs that are equally effective as painkillers but that have less risk of physical dependence and potential for abuse. Following are several of these. Me R = H; Morphine R = CH3; Codeine OH OR Me -N-Me Me N-Me Me OEt Meperidine (Demerol) Methadone Propoxyphene (Darvon)

Morphine and its O-methylated derivative codeine are among the most effective pain- killers known. However, they possess two serious drawbacks: they are addictive, and repeated use induces a tolerance to the drug. Many morphine analogs have been pre- pared in an effort to find drugs that are equally effective as painkillers but that have less risk of physical dependence and potential for abuse. Following are several of these. Me R = H; Morphine R = CH3; Codeine OH OR Me -N-Me Me N-Me Me OEt Meperidine (Demerol) Methadone Propoxyphene (Darvon)

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter10: Alcohols

Section: Chapter Questions

Problem 10.58P

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