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Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms) which would be the best ligand for Hg(1) and Hg(II), and why? H3N- CH2 H H3N--c CH2 H3Nt-C-c CH2 CH2 CH2 H3N CH2 но CH3 SH он H2N Serine (S) Ser Threonine (T) Cysteine (C) Tyrosine (Y) Asparagine (N) Glutamine (Q) Тyr Thr Cys Asn Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts. (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)

Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms) which would be the best ligand for Hg(1) and Hg(II), and why? H3N- CH2 H H3N--c CH2 H3Nt-C-c CH2 CH2 CH2 H3N CH2 но CH3 SH он H2N Serine (S) Ser Threonine (T) Cysteine (C) Tyrosine (Y) Asparagine (N) Glutamine (Q) Тyr Thr Cys Asn Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts. (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Problem 4: Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms), which would be the best ligand for Hg(1) and Hg(II), and why? H -ド H3Nt--c CH2 H3N-C-c CH2 H3N* CH2 CH2 H3Nt- CH2 он HO CH3 SH он H2N H2N Threonine (T) Serine (S) Ser Cysteine (C) Tyrosine (Y) Asparagine (N) Glutamine (Q) Cys Thr Тyr Asn Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts. (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)
Transcribed Image Text:Problem 4: Mercury ions, Hg(1) and Hg(II), are poisonous due to their ability to displace other metal ions in enzymes and disrupt the biological function. a) Are these ions hard or soft? b) Common ligands for metal ions in biological environments are amino acids (building blocks of proteins). Of the amino acids depicted below (focus on the highlighted atoms), which would be the best ligand for Hg(1) and Hg(II), and why? H -ド H3Nt--c CH2 H3N-C-c CH2 H3N* CH2 CH2 H3Nt- CH2 он HO CH3 SH он H2N H2N Threonine (T) Serine (S) Ser Cysteine (C) Tyrosine (Y) Asparagine (N) Glutamine (Q) Cys Thr Тyr Asn Gln c) Other metal ions that are toxic at certain concentrations include cadmium, chromium, iron, arsenic, and lead. For each of these metals, predict whether they would have similar chemistry to mercury using HSAB concepts. (Note that toxicity is dose-dependent; even water can be poisonous at too high a concentration in the body)
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