Diazepam, better known as Valium, is a central nervous system (CNS) sedative/ hypnotic. As a sedative, it diminishes activity and excitement and thereby has a calming effect. Back in 1976, based on the number of new and refilled prescriptions processed,
diazepam was the most prescribed drug in the United States. Following is a retrosynthetic analysis for a synthesis of diazepam. Note that the formation of compound B involves a Friedel-Crafts acylation. In this reaction, it is necessary to protect the 2°
Q.Given this retrosynthetic analysis, propose a synthesis for diazepam
![Me
Me
Me
Cl
CI
CI
(A)
(В)
Diazepam
Cl-
Me
CI
4-Chloro-N-methylaniline
Benzoyl chloride](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F4081dfd3-eb0d-4476-a604-93fcbb28556e%2Fcf55c9fe-6b0c-44f4-af3e-82b9f24659a5%2F9rx931o_processed.jpeg&w=3840&q=75)
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