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Macmillan Learning Arrange the steps to outline the mechanism by which ribonucleotide reductase converts a ribonucleotide to a deoxyribonucleotide. A ribonucleotide enters the active site of ribonucleotide reductase. The cysteine radical abstracts a hydrogen atom from C-3' of the substrate, forming a radical. C-2' of the substrate releases an OH. C-2' accepts a hydride ion from a cysteine residue. A hydrogen atom binds to C-3' of the substrate. The tyrosyl radical on R2 accepts an electron from a cysteine on R1. A deoxyribonucleotide exits the active site of ribonucleotide reductase.

Macmillan Learning Arrange the steps to outline the mechanism by which ribonucleotide reductase converts a ribonucleotide to a deoxyribonucleotide. A ribonucleotide enters the active site of ribonucleotide reductase. The cysteine radical abstracts a hydrogen atom from C-3' of the substrate, forming a radical. C-2' of the substrate releases an OH. C-2' accepts a hydride ion from a cysteine residue. A hydrogen atom binds to C-3' of the substrate. The tyrosyl radical on R2 accepts an electron from a cysteine on R1. A deoxyribonucleotide exits the active site of ribonucleotide reductase.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Macmillan Learning Arrange the steps to outline the mechanism by which ribonucleotide reductase converts a ribonucleotide to a deoxyribonucleotide. A ribonucleotide enters the active site of ribonucleotide reductase. The cysteine radical abstracts a hydrogen atom from C-3' of the substrate, forming a radical. C-2' of the substrate releases an OH. C-2' accepts a hydride ion from a cysteine residue. A hydrogen atom binds to C-3' of the substrate. The tyrosyl radical on R2 accepts an electron from a cysteine on R1. A deoxyribonucleotide exits the active site of ribonucleotide reductase.
Transcribed Image Text:Macmillan Learning Arrange the steps to outline the mechanism by which ribonucleotide reductase converts a ribonucleotide to a deoxyribonucleotide. A ribonucleotide enters the active site of ribonucleotide reductase. The cysteine radical abstracts a hydrogen atom from C-3' of the substrate, forming a radical. C-2' of the substrate releases an OH. C-2' accepts a hydride ion from a cysteine residue. A hydrogen atom binds to C-3' of the substrate. The tyrosyl radical on R2 accepts an electron from a cysteine on R1. A deoxyribonucleotide exits the active site of ribonucleotide reductase.
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