LO 53- Determine the type of mutations based on the effect in the amino acid chain "missense, nonsense, silent and neutral" - that occurred in a sequence. Which of the following types of mutations leads to a shorter protein than the original? gain-of-function mutation O neutral mutation Osilent mutation Ononsense mutation missense mutation

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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53.
### Understanding Mutations and Their Effects on Protein Synthesis

**Objective:**
Determine the type of mutations based on their effects on the amino acid chain, specifically focusing on missense, nonsense, silent, and neutral mutations.

**Question:**
Which of the following types of mutations lead to a shorter protein than the original?

**Options:**

- ○ Gain-of-function mutation
- ○ Neutral mutation
- ○ Silent mutation
- ○ Nonsense mutation
- ○ Missense mutation

**Explanation:**
A **nonsense mutation** is a type of mutation that leads to a premature stop codon, resulting in a shorter, truncated protein. This is in contrast to other mutations: 

- **Gain-of-function mutation** can increase protein activity or create new functions.
- **Neutral mutation** does not affect the protein significantly.
- **Silent mutation** alters the DNA sequence without changing the amino acid sequence.
- **Missense mutation** results in a single amino acid change but doesn't necessarily shorten the protein.

Understanding these distinctions is crucial for recognizing how genetic mutations influence protein synthesis and function.
Transcribed Image Text:### Understanding Mutations and Their Effects on Protein Synthesis **Objective:** Determine the type of mutations based on their effects on the amino acid chain, specifically focusing on missense, nonsense, silent, and neutral mutations. **Question:** Which of the following types of mutations lead to a shorter protein than the original? **Options:** - ○ Gain-of-function mutation - ○ Neutral mutation - ○ Silent mutation - ○ Nonsense mutation - ○ Missense mutation **Explanation:** A **nonsense mutation** is a type of mutation that leads to a premature stop codon, resulting in a shorter, truncated protein. This is in contrast to other mutations: - **Gain-of-function mutation** can increase protein activity or create new functions. - **Neutral mutation** does not affect the protein significantly. - **Silent mutation** alters the DNA sequence without changing the amino acid sequence. - **Missense mutation** results in a single amino acid change but doesn't necessarily shorten the protein. Understanding these distinctions is crucial for recognizing how genetic mutations influence protein synthesis and function.
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