LO 53- Determine the type of mutations based on the effect in the amino acid chain "missense, nonsense, silent and neutral" - that occurred in a sequence. Which of the following types of mutations leads to a shorter protein than the original? gain-of-function mutation O neutral mutation Osilent mutation Ononsense mutation missense mutation
LO 53- Determine the type of mutations based on the effect in the amino acid chain "missense, nonsense, silent and neutral" - that occurred in a sequence. Which of the following types of mutations leads to a shorter protein than the original? gain-of-function mutation O neutral mutation Osilent mutation Ononsense mutation missense mutation
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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53.

Transcribed Image Text:### Understanding Mutations and Their Effects on Protein Synthesis
**Objective:**
Determine the type of mutations based on their effects on the amino acid chain, specifically focusing on missense, nonsense, silent, and neutral mutations.
**Question:**
Which of the following types of mutations lead to a shorter protein than the original?
**Options:**
- ○ Gain-of-function mutation
- ○ Neutral mutation
- ○ Silent mutation
- ○ Nonsense mutation
- ○ Missense mutation
**Explanation:**
A **nonsense mutation** is a type of mutation that leads to a premature stop codon, resulting in a shorter, truncated protein. This is in contrast to other mutations:
- **Gain-of-function mutation** can increase protein activity or create new functions.
- **Neutral mutation** does not affect the protein significantly.
- **Silent mutation** alters the DNA sequence without changing the amino acid sequence.
- **Missense mutation** results in a single amino acid change but doesn't necessarily shorten the protein.
Understanding these distinctions is crucial for recognizing how genetic mutations influence protein synthesis and function.
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