Liposomes can be made by vigorously mixing phospholipids(like phosphatidylcholine) in water. When the mixture isallowed to settle, spherical vesicles form that are surroundedby a phospholipid bilayer “membrane.” Pharmaceuticalchemists are trying to develop liposomes as a targeted drugdelivery system. By adding the drug of choice to the mixturedescribed above, liposomes form around the solution of thedrug. Specific proteins can be incorporated into the mixturethat will end up within the phospholipid bilayers of theliposomes. These proteins are able to bind to targets on thesurface of particular kinds of cells in the body. Explain whyinjection of liposome encapsulated pharmaceuticals mightbe a good drug delivery system.
Liposomes can be made by vigorously mixing phospholipids
(like phosphatidylcholine) in water. When the mixture is
allowed to settle, spherical vesicles form that are surrounded
by a phospholipid bilayer “membrane.” Pharmaceutical
chemists are trying to develop liposomes as a targeted drug
delivery system. By adding the drug of choice to the mixture
described above, liposomes form around the solution of the
drug. Specific proteins can be incorporated into the mixture
that will end up within the phospholipid bilayers of the
liposomes. These proteins are able to bind to targets on the
surface of particular kinds of cells in the body. Explain why
injection of liposome encapsulated pharmaceuticals might
be a good drug delivery system.
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