KL is a 51-year-old female (weight = 75 kg; height = 5 ft 10 in) with a history of epileptic seizures who requires therapy with oral valproic acid. She has reduced liver function and takes no medications. Suggest an initial valproic acid dosage regimen designed to achieve an average steady-state valproic acid concentration equal to 50 mcg/mL assuming a theoretical bioavailability of 80%, an estimated clearance of 0.4 mL/hr, and volume of distribution of 0.2 L/kg. Calculate the patient-specific maintenance dose, assuming a dosing interval of 12 hours (be sure to include your units!!)
KL is a 51-year-old female (weight = 75 kg; height = 5 ft 10 in) with a history of epileptic seizures who requires therapy with oral valproic acid. She has reduced liver function and takes no medications. Suggest an initial valproic acid dosage regimen designed to achieve an average steady-state valproic acid concentration equal to 50 mcg/mL assuming a theoretical bioavailability of 80%, an estimated clearance of 0.4 mL/hr, and volume of distribution of 0.2 L/kg. Calculate the patient-specific maintenance dose, assuming a dosing interval of 12 hours (be sure to include your units!!)
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
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Transcribed Image Text:KL is a 51-year-old female (weight = 75 kg: height = 5 ft 10 in) with a history of epileptic seizures who
requires therapy with oral valproic acid. She has reduced liver function and takes no medications.
Suggest an initial valproic acid dosage regimen designed to achieve an average steady-state
valproic acid concentration equal to 50 mcg/mL assuming a theoretical bioavailability of 80%, an
estimated clearance of 0.4 mL/hr, and volume of distribution of 0.2 L/kg.
Calculate the patient-specific maintenance dose, assuming a dosing interval of 12 hours (be sure to
include your units!!)
DON'T DO HANDWRITEEN ONLY TYPED ANSWER
WRONG ANSWER = DOWNVOTES
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