King Charles (K), in the pedigree shown, is a heterozygous carrier of porphyria, a recessive metabolic disorder. His genotype is therefore P+/P¹ (P' is the porphyria allele). Queen Charlotte (Q), Charles' wife, is homozygous for nonporphyria, her genotype is P+/ P+. What is the inbreeding coefficient of their great-grandson, Olaf (O)?

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Inheritance and Mendelian Genetics

Inheritance means the passing of traits to offspring from parents. These traits could be passed either through asexual reproduction or sexual reproduction. The offspring receives the genetic material from the parents. Mendelian inheritance is a certain biological inheritance that follows the rules and principles laid down by Gregor Mendel in 1865. The initial hypothesis was considered wrong, but other inheritance theories modified the concept of inheritance and thus genetics.