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k- j- i- н Н ОН OH OH ОН PCC CrO3 H2504 H2O 1 equiv. TMS-CI, NET3

k- j- i- н Н ОН OH OH ОН PCC CrO3 H2504 H2O 1 equiv. TMS-CI, NET3

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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The image contains three chemical reactions involving the oxidation of alcohols. Here is a detailed transcription and explanation: 1. **Reaction k:** - **Reactant:** A secondary alcohol with a cyclohexyl ring. - **Reagent:** PCC (Pyridinium chlorochromate). - **Reaction Direction:** The arrow indicates the transformation of the alcohol under the influence of PCC. - **Description:** This reaction involves the oxidation of the secondary alcohol to form a ketone. 2. **Reaction j:** - **Reactant:** A secondary alcohol with a cyclohexyl ring. - **Reagents:** CrO₃ (Chromium trioxide), H₂SO₄ (Sulfuric acid), and H₂O (water). - **Reaction Direction:** The arrow shows the progression of the oxidation process. - **Description:** This is a strong oxidation reaction leading to the formation of a ketone, using a chromium-based oxidizing agent in acidic conditions. 3. **Reaction i:** - **Reactant:** A diol (a compound with two hydroxyl groups). - **Reagent:** 1 equivalent of TMS-Cl (Trimethylsilyl chloride) and NEt₃ (Triethylamine). - **Reaction Direction:** The arrow demonstrates the transformation facilitated by the silylating agent. - **Description:** This reaction involves the protection of the alcohol groups by converting them into silyl ethers, which are more resistant to oxidation. This is useful in multistep synthesis to temporarily block the reactivity of alcohols. Each reaction highlights different strategies for oxidizing or protecting alcohol groups in organic chemistry.
Transcribed Image Text:The image contains three chemical reactions involving the oxidation of alcohols. Here is a detailed transcription and explanation: 1. **Reaction k:** - **Reactant:** A secondary alcohol with a cyclohexyl ring. - **Reagent:** PCC (Pyridinium chlorochromate). - **Reaction Direction:** The arrow indicates the transformation of the alcohol under the influence of PCC. - **Description:** This reaction involves the oxidation of the secondary alcohol to form a ketone. 2. **Reaction j:** - **Reactant:** A secondary alcohol with a cyclohexyl ring. - **Reagents:** CrO₃ (Chromium trioxide), H₂SO₄ (Sulfuric acid), and H₂O (water). - **Reaction Direction:** The arrow shows the progression of the oxidation process. - **Description:** This is a strong oxidation reaction leading to the formation of a ketone, using a chromium-based oxidizing agent in acidic conditions. 3. **Reaction i:** - **Reactant:** A diol (a compound with two hydroxyl groups). - **Reagent:** 1 equivalent of TMS-Cl (Trimethylsilyl chloride) and NEt₃ (Triethylamine). - **Reaction Direction:** The arrow demonstrates the transformation facilitated by the silylating agent. - **Description:** This reaction involves the protection of the alcohol groups by converting them into silyl ethers, which are more resistant to oxidation. This is useful in multistep synthesis to temporarily block the reactivity of alcohols. Each reaction highlights different strategies for oxidizing or protecting alcohol groups in organic chemistry.
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