Ison, asse oxygen; (4) ATP synthase; and finally, do you predict it to be fatal to humans?. 1. Cyanide: binds to Cytochrome C (complex IV), and deactivates it. NADH levels: H. Gradient: Reduction of O2: ATP Synthase:

Biochemistry
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ISBN:9781319114671
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Chapter1: Biochemistry: An Evolving Science
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**For each poison, assess impact on (1) input (NADH, electrons); (2) H+ gradient; (3) reduction of oxygen; (4) ATP synthase; and finally, do you predict it to be fatal to humans?**

**1. Cyanide: binds to Cytochrome C (complex IV), and deactivates it.**

- **NADH levels:**

- **H+ Gradient:**

- **Reduction of O₂:**

- **ATP Synthase:**

- **Fatal?**

**Explanation:**

This section evaluates the impact of cyanide on cellular respiration. Cyanide binds to Cytochrome C (complex IV) in the electron transport chain, inhibiting its function. This blockage affects several processes:

1. **NADH levels:** The inhibition could lead to an accumulation of NADH since electrons can't flow through the chain.
   
2. **H+ Gradient:** The proton gradient across the mitochondrial membrane is disrupted, reducing the potential for ATP synthesis.
   
3. **Reduction of O₂:** Cyanide prevents the reduction of oxygen to water, halting electron transport.
   
4. **ATP Synthase:** Without the proton gradient, ATP synthase cannot produce ATP efficiently, leading to energy deficits.

5. **Fatal?** Yes, cyanide poisoning is typically fatal if not treated promptly due to its critical disruption of cellular respiration.
Transcribed Image Text:**For each poison, assess impact on (1) input (NADH, electrons); (2) H+ gradient; (3) reduction of oxygen; (4) ATP synthase; and finally, do you predict it to be fatal to humans?** **1. Cyanide: binds to Cytochrome C (complex IV), and deactivates it.** - **NADH levels:** - **H+ Gradient:** - **Reduction of O₂:** - **ATP Synthase:** - **Fatal?** **Explanation:** This section evaluates the impact of cyanide on cellular respiration. Cyanide binds to Cytochrome C (complex IV) in the electron transport chain, inhibiting its function. This blockage affects several processes: 1. **NADH levels:** The inhibition could lead to an accumulation of NADH since electrons can't flow through the chain. 2. **H+ Gradient:** The proton gradient across the mitochondrial membrane is disrupted, reducing the potential for ATP synthesis. 3. **Reduction of O₂:** Cyanide prevents the reduction of oxygen to water, halting electron transport. 4. **ATP Synthase:** Without the proton gradient, ATP synthase cannot produce ATP efficiently, leading to energy deficits. 5. **Fatal?** Yes, cyanide poisoning is typically fatal if not treated promptly due to its critical disruption of cellular respiration.
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