Investigators are interested in the agreement between a well-established and validated yet expensive approach (assay 1) for diagnosing a disease and a new less invasive and less expensive approach (assay 2).  A total of 200 patients were evaluated using both assays, and the results are shown in the table below.   Assay 1   Assay 2 Positive Negative Total                 Positive 102 20 122                 Negative 16 62 78                 Total 118 82 200

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