Indicate the correct set of reactions from the choices below that would accomplish the following synthesis MOST efficiently (Hint: what is the MAJOR product of each step). (+ enantiomer) Product Starting Material O1. MeMgBr then HCI, 2. H2SO4, heat, 3. NBS, peroxide, heat O1. H,SO4. MEOH, 2. POCI3, pyridine, 3. HBr, CH,00CH3, heat O1. MeMgBr then HCI, 2. H,SO4, heat, 2. HBr, peroxide, light O1. Meli then H,0, 2. TsCI, pyridine 3. NaBr (excess), heat O1. LIAIH4 then H20, 2. H,SO4, heat, 3. HBr

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Indicate the correct set of reactions from the choices below that would accomplish
the following synthesis MOST efficiently (Hint: what is the MAJOR product of each
step).
(+ enantiomer)
Product
Starting Material
O1. MeMgBr then HCI, 2. H2SO4, heat, 3. NBS, peroxide, heat
O1. H,SO4. MEOH, 2. POCI3, pyridine, 3. HBr, CH,00CH3, heat
O1. MeMgBr then HCI, 2. H,SO4, heat, 2. HBr, peroxide, light
O1. Meli then H,0, 2. TSCI, pyridine 3. NaBr (excess), heat
O1. LIAIH4 then H20, 2. H,SO4, heat, 3. HBr
Transcribed Image Text:Indicate the correct set of reactions from the choices below that would accomplish the following synthesis MOST efficiently (Hint: what is the MAJOR product of each step). (+ enantiomer) Product Starting Material O1. MeMgBr then HCI, 2. H2SO4, heat, 3. NBS, peroxide, heat O1. H,SO4. MEOH, 2. POCI3, pyridine, 3. HBr, CH,00CH3, heat O1. MeMgBr then HCI, 2. H,SO4, heat, 2. HBr, peroxide, light O1. Meli then H,0, 2. TSCI, pyridine 3. NaBr (excess), heat O1. LIAIH4 then H20, 2. H,SO4, heat, 3. HBr
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