In the mechanism of the Claisen condensation reaction, which step is the one that drives the reaction to completion? O Step 4 - deprotonation of the beta-ketoester to form another enolate O Step 2 - attack of the nucleophilic enolate on a second equivalent of ester to form a tetrahedral intermediate O Step 1 - deprotonation of the ester to form an enolate Step 3 - collapse of the tetrahedral intermediate to form a beta-ketoester Step 5 - protonation of the second enolate to reform the beta-ketoester
In the mechanism of the Claisen condensation reaction, which step is the one that drives the reaction to completion? O Step 4 - deprotonation of the beta-ketoester to form another enolate O Step 2 - attack of the nucleophilic enolate on a second equivalent of ester to form a tetrahedral intermediate O Step 1 - deprotonation of the ester to form an enolate Step 3 - collapse of the tetrahedral intermediate to form a beta-ketoester Step 5 - protonation of the second enolate to reform the beta-ketoester
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:In the mechanism of the Claisen condensation reaction, which step is the one that
drives the reaction to completion?
Step 4 - deprotonation of the beta-ketoester to form another enolate
Step 2 - attack of the nucleophilic enolate on a second equivalent of ester to form
a tetrahedral intermediate
Step 1 - deprotonation of the ester to form an enolate
O Step 3 - collapse of the tetrahedral intermediate to form a beta-ketoester
Step 5 - protonation of the second enolate to reform the beta-ketoester
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