In the mechanism of the Claisen condensation reaction, which step is the one that drives the reaction to completion? O Step 4 - deprotonation of the beta-ketoester to form another enolate O Step 2 - attack of the nucleophilic enolate on a second equivalent of ester to form a tetrahedral intermediate O Step 1 - deprotonation of the ester to form an enolate Step 3 - collapse of the tetrahedral intermediate to form a beta-ketoester Step 5 - protonation of the second enolate to reform the beta-ketoester

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In the mechanism of the Claisen condensation reaction, which step is the one that
drives the reaction to completion?
Step 4 - deprotonation of the beta-ketoester to form another enolate
Step 2 - attack of the nucleophilic enolate on a second equivalent of ester to form
a tetrahedral intermediate
Step 1 - deprotonation of the ester to form an enolate
O Step 3 - collapse of the tetrahedral intermediate to form a beta-ketoester
Step 5 - protonation of the second enolate to reform the beta-ketoester
Transcribed Image Text:In the mechanism of the Claisen condensation reaction, which step is the one that drives the reaction to completion? Step 4 - deprotonation of the beta-ketoester to form another enolate Step 2 - attack of the nucleophilic enolate on a second equivalent of ester to form a tetrahedral intermediate Step 1 - deprotonation of the ester to form an enolate O Step 3 - collapse of the tetrahedral intermediate to form a beta-ketoester Step 5 - protonation of the second enolate to reform the beta-ketoester
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