In sickle cell anemia, hemoglobin forms long fibers as a result of Burying of non-polar amino acids Electrostatic interaction between glutamate and non polar amino acids Exposing polar amino acids Burying polar amino acids
In sickle cell anemia, hemoglobin forms long fibers as a result of Burying of non-polar amino acids Electrostatic interaction between glutamate and non polar amino acids Exposing polar amino acids Burying polar amino acids
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Transcribed Image Text:In sickle cell anemia, hemoglobin forms long fibers as a result of
Burying of non-polar amino acids
Electrostatic interaction between glutamate and non polar amino acids
Exposing polar amino acids
Burying polar amino acids
Expert Solution
Step 1: Introduction:
Sickle cell anemia is a hereditary blood disorder characterized by the abnormal shape of red blood cells and associated health complications. One of the defining features of this condition is the polymerization of hemoglobin molecules, leading to the formation of long fibers under specific conditions. Understanding the mechanism behind this polymerization is crucial for comprehending the pathophysiology of sickle cell anemia and its clinical manifestations.
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