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In class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number of ATPS you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P ATP ADP Aldolase B Dihydroxy- Glyceraldehyde ATP N acetone phosphate Triose kinase Triose ADP to phosphate isomerase - Glyceraldehyde-3-P Glycolysis Pyruvate Acetyl-CoA Fatty acids and triglycerides

In class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number of ATPS you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P ATP ADP Aldolase B Dihydroxy- Glyceraldehyde ATP N acetone phosphate Triose kinase Triose ADP to phosphate isomerase - Glyceraldehyde-3-P Glycolysis Pyruvate Acetyl-CoA Fatty acids and triglycerides

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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See how I calculated ATP for glucose, follow that to calculate ATP for fructose. Remember, fructose ends up in acetyl coA but doesn't go through krebs cycle, instead gets tracked for fatty acid synthesis.

therefore, We get low ATP 

In class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number ofATPs you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P АТР ADP Aldolase B Dihydroxy- acetone phosphate Glyceraldehyde АТР Triose kinase Triose phosphate isomerase ADP 4 - Glyceraldehyde-3-P Glycolysis Руruvate Acetyl-CoA Fatty acids and triglycerides
Transcribed Image Text:In class, I mentioned that fructose is metabolized differently in the liver compared to glucose. Refer to the figure shown below to calculate the number ofATPs you would expect from the metabolism of fructose in the liver. Show your work! Fructokinase Fructose Fructose-1-P АТР ADP Aldolase B Dihydroxy- acetone phosphate Glyceraldehyde АТР Triose kinase Triose phosphate isomerase ADP 4 - Glyceraldehyde-3-P Glycolysis Руruvate Acetyl-CoA Fatty acids and triglycerides
Adding it all up... Glycolysis... 2 ATP 8 ATP 2 NADH (x 3 ATP/ NADH) = 6 ATP (and 2 pyruvate which goes to... PDH... 1 NADH / pyruvate 2 pyruvates; so... 2 NADH (x 3 ATP/ NADH) = 6 ATP (and 2 acetyl-CoA which goes to...) 6 ATP Krebs cycle... 3 NADH / acetyl-CoA 1 FADH, / acetyl-CoA 1 ATP/ acetyl-CoA 3 NADH (x 3 ATP /NADH) = 9 ATP 1 FADH, (x 2 ATP / FADH,) = 2 ATP 1 ATP 12 ΑTΡ per acetyl- CoA But 2 actyl-CoA! So multiply 12 ATP by 2... 24 ATP Grand total: 8 ATP (from glycolysis) 6 ATP (from PDH) 24 ATP (from Krebs cycle) 38 ATP! (mostly from oxidation of
Transcribed Image Text:Adding it all up... Glycolysis... 2 ATP 8 ATP 2 NADH (x 3 ATP/ NADH) = 6 ATP (and 2 pyruvate which goes to... PDH... 1 NADH / pyruvate 2 pyruvates; so... 2 NADH (x 3 ATP/ NADH) = 6 ATP (and 2 acetyl-CoA which goes to...) 6 ATP Krebs cycle... 3 NADH / acetyl-CoA 1 FADH, / acetyl-CoA 1 ATP/ acetyl-CoA 3 NADH (x 3 ATP /NADH) = 9 ATP 1 FADH, (x 2 ATP / FADH,) = 2 ATP 1 ATP 12 ΑTΡ per acetyl- CoA But 2 actyl-CoA! So multiply 12 ATP by 2... 24 ATP Grand total: 8 ATP (from glycolysis) 6 ATP (from PDH) 24 ATP (from Krebs cycle) 38 ATP! (mostly from oxidation of
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