In a species of beetle, the size and color of the wings are controlled by two distinct genes. There are two alleles for the size gene: the big allele makes wings large, and the small allele makes them smaller. There are two alleles for the color gene: red and yellow. You are able to estimate the frequency of the four haplotypes from a museum collection from 60 years ago. You also estimate haplotype frequencies in the present day. The data are shown in the table below. Museum (60 ya) Present day big/red 0.69 0.5452 big/yellow 0.00 0.1448 small/red 0.09 0.2348 small/yellow 0.22 0.0752 A) What is linkage disequilibrium (LD) between the size and color loci in the museum collection? What is LD in the present day? B) Assuming one generation per year, what is the recombination fraction between the size and color loci?

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In a species of beetle, the size and color of the wings are controlled by two distinct genes.
There are two alleles for the size gene: the big allele makes wings large, and the small allele
makes them smaller. There are two alleles for the color gene: red and yellow. You are able
to estimate the frequency of the four haplotypes from a museum collection from 60 years
ago. You also estimate haplotype frequencies in the present day. The data are shown in the
table below.
Museum (60 ya)
Present day
big/red
0.69
0.5452
big/yellow
0.00
0.1448
small/red
0.09
0.2348
small/yellow
0.22
0.0752
A) What is linkage disequilibrium (LD) between the size and color loci in the museum
collection? What is LD in the present day?
B) Assuming one generation per year, what is the recombination fraction between the
size and color loci?
Transcribed Image Text:In a species of beetle, the size and color of the wings are controlled by two distinct genes. There are two alleles for the size gene: the big allele makes wings large, and the small allele makes them smaller. There are two alleles for the color gene: red and yellow. You are able to estimate the frequency of the four haplotypes from a museum collection from 60 years ago. You also estimate haplotype frequencies in the present day. The data are shown in the table below. Museum (60 ya) Present day big/red 0.69 0.5452 big/yellow 0.00 0.1448 small/red 0.09 0.2348 small/yellow 0.22 0.0752 A) What is linkage disequilibrium (LD) between the size and color loci in the museum collection? What is LD in the present day? B) Assuming one generation per year, what is the recombination fraction between the size and color loci?
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