Answered: In a particular human family, John and…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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In a particular human family, John and his mother
both have brachydactyly (a rare autosomal dominant allele causing short fingers). John’s father has
Huntington disease (another rare autosomal dominant allele). John’s wife is phenotypically normal
and is pregnant. Two-thirds of people who inherit
the Huntington (HD) allele show symptoms by age
50, and John is 50 and has no symptoms.
Brachydactyly is 90% penetrant.
a. What are the genotypes of John’s parents?
b. What are the possible genotypes for John? How
likely is John to have each of these genotypes?
c. What is the probability the child will express both
brachydactyly and Huntington disease by age 50 if
the two genes are unlinked?
d. How will your answer to part (c) change if instead
these two loci are 20 m.u. apart?

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