In a first –order reaction, suppose that a quantity X of a reactant is added at regular intervals of time, Δt. At first the amount of reactant in the system builds up; eventually, however, it levels off at a saturation value given by the expression Saturation value = x / (1 -10-a) where a = 0.30 Δt/t1/2 This analysis applies to prescription drugs, of which you take a certain amount each day. Suppose that you take 0.100 g of a drug three times a day and that the half-life for elimination is 2.0 days. Using this equation, calculate the mass of the drug in the body at saturation. Suppose further that side effects show up when 0.500 g of the drug accumulates in the body. As a pharmacist, what is the maximum dosage you could assign to a patient for an 8-h period without causing side effects?
In a first –order reaction, suppose that a quantity X of a reactant is added at regular intervals
of time, Δt. At first the amount of reactant in the system builds up; eventually, however, it levels
off at a saturation value given by the expression
Saturation value = x / (1 -10-a) where a = 0.30 Δt/t1/2
This analysis applies to prescription drugs, of which you take a certain amount each day. Suppose
that you take 0.100 g of a drug three times a day and that the half-life for elimination is 2.0 days.
Using this equation, calculate the mass of the drug in the body at saturation. Suppose further
that side effects show up when 0.500 g of the drug accumulates in the body. As a pharmacist,
what is the maximum dosage you could assign to a patient for an 8-h period without causing side
effects?
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