Answered: Identify the major and minor grooves in…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

https://www.rcsb.org/structure/141D

Identify the major and minor grooves in the DNA molecule PDB ID 141D. In addition, one end of a strand is shown magnified
and rotated. Identify whether it is the 5' end or the 3' end, and identify the base.
Access PDB ID 145D, a DNA with the Z conformation.
3' thymine
5' adenine
3' guanine
Answer Bank
s' cytosinc
major groove
minor groove

Transcribed Image Text:Elucidation of the three-dimensional structure of DNA helped researchers understand how this molecule conveys information that can be faithfully replicated from one generation to the next. To see the secondary structure of double-stranded DNA, go to the Protein Data Bank (PDB) website. Use the PDB identifier provided in each question to retrieve the structure summary for a double-stranded DNA segment. View each 3D structure using JSmol. Select the 3D View tab and toggle the viewer to JSmol. The viewer select menu is below the right corner of the image box. Once in JSmol, you will need to use both the display options on the screen and the scripting controls in the JSmol menu. For each molecule, set the Style to Ball and Stick using the display options menu. Next, access the JSmol menu by clicking on the JSmol logo in the lower right corner of the image screen. Use the scripting controls to color by element (Color → Atoms → By Scheme → Element (CPK)). Refer to the JSmol help links as needed. Access PDB ID 141D, a highly conserved, repeated DNA sequence from the end of the genome of HIV-1 (the virus that causes AIDS). Is PDB ID 141D a right-handed helix or a left-handed helix? right-handed helix left-handed helix

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