Identify the functional groups

Macroscale and Microscale Organic Experiments
7th Edition
ISBN:9781305577190
Author:Kenneth L. Williamson, Katherine M. Masters
Publisher:Kenneth L. Williamson, Katherine M. Masters
Chapter7: Extraction
Section: Chapter Questions
Problem 10Q
icon
Related questions
icon
Concept explainers
Question
Identify the functional groups and predict the solubility of Amoxicillin. Please see tha table for guide and the examples. Examine very well. Provide drawings and explanation please thank u very much. Efforts are highly appreciated.
pi Value
Fragment
C (aliphatic/cyclic)
+0.5
C (alkene-aliphatic/cyclic)
+0.33
(phenyl/benzene ring) C,H;-
+2.0
>/= to +0.5
Halogens (CI, F, Br)
+0.5
water insoluble
O,NO
+0.2
Intramolecular hydrogen bonding (IMHB)
+0.65
< +0.5
+0.5
water soluble
(carboxylic acid) O=C-O
-0.7
(amide) O=C-N
-0.7
O(hydroxyl, phenol, ether)
-1.0
N (amine-aliphatic/cyclic/aromatic)
-1.0
O,N (aliphatic)
-0.85
0,N (aromatic)
-0.28
Benzene 2
TOTAL: 3.95
WATER INSOLUBLE
C-aliphatic=0.5
N cyclic= -1
N
O=CN = -0.7
Benzene 2
HMHB= 0,65
C-aliphatic=0.5
Total: 5.28
Carbon
aliphatice
05
WATER INSOLUBLE
H,CO
Carbon
aliphatic=
0.5
Cyclic
alkene=0.33
H,CO
Carbon
alphatic=
OCH 05
OCN=-0.7
Carbon
OCH3 aliphatic=
6.5
Carbon
cyclic= 0.5
H.C
Benzene=2
Carbon
aliphatice
IMHB= 0.65
0.5
I ZI
Transcribed Image Text:pi Value Fragment C (aliphatic/cyclic) +0.5 C (alkene-aliphatic/cyclic) +0.33 (phenyl/benzene ring) C,H;- +2.0 >/= to +0.5 Halogens (CI, F, Br) +0.5 water insoluble O,NO +0.2 Intramolecular hydrogen bonding (IMHB) +0.65 < +0.5 +0.5 water soluble (carboxylic acid) O=C-O -0.7 (amide) O=C-N -0.7 O(hydroxyl, phenol, ether) -1.0 N (amine-aliphatic/cyclic/aromatic) -1.0 O,N (aliphatic) -0.85 0,N (aromatic) -0.28 Benzene 2 TOTAL: 3.95 WATER INSOLUBLE C-aliphatic=0.5 N cyclic= -1 N O=CN = -0.7 Benzene 2 HMHB= 0,65 C-aliphatic=0.5 Total: 5.28 Carbon aliphatice 05 WATER INSOLUBLE H,CO Carbon aliphatic= 0.5 Cyclic alkene=0.33 H,CO Carbon alphatic= OCH 05 OCN=-0.7 Carbon OCH3 aliphatic= 6.5 Carbon cyclic= 0.5 H.C Benzene=2 Carbon aliphatice IMHB= 0.65 0.5 I ZI
Amoxicillin
NH2 H
N.
.CH3
N-
CH3
НО
co,H
Identify the functional groups present in each
drug and predict the drug solubility based on the
given table. (See attached examples)
Transcribed Image Text:Amoxicillin NH2 H N. .CH3 N- CH3 НО co,H Identify the functional groups present in each drug and predict the drug solubility based on the given table. (See attached examples)
Expert Solution
steps

Step by step

Solved in 3 steps with 2 images

Blurred answer
Knowledge Booster
Lipids
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Macroscale and Microscale Organic Experiments
Macroscale and Microscale Organic Experiments
Chemistry
ISBN:
9781305577190
Author:
Kenneth L. Williamson, Katherine M. Masters
Publisher:
Brooks Cole
Chemistry for Engineering Students
Chemistry for Engineering Students
Chemistry
ISBN:
9781337398909
Author:
Lawrence S. Brown, Tom Holme
Publisher:
Cengage Learning
Chemistry by OpenStax (2015-05-04)
Chemistry by OpenStax (2015-05-04)
Chemistry
ISBN:
9781938168390
Author:
Klaus Theopold, Richard H Langley, Paul Flowers, William R. Robinson, Mark Blaser
Publisher:
OpenStax
EBK A SMALL SCALE APPROACH TO ORGANIC L
EBK A SMALL SCALE APPROACH TO ORGANIC L
Chemistry
ISBN:
9781305446021
Author:
Lampman
Publisher:
CENGAGE LEARNING - CONSIGNMENT
General, Organic, and Biological Chemistry
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
Organic And Biological Chemistry
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,