I-1 1-2 П-1 П-2 П-3 П-4 П-5 П-6 П-7 III -1 III-2 Ш-3 Ш-4 Ш-5 Ш-6 Ш-7 Ш-8 A. Based on this pedigree, does this syndrome appear to follow autosomal recessive, autosomal dominant, X-linked recessive, or X-linked dominant inheritance? Explain your reasoning. B. What is the likelihood that II-1, II-2, II-3, II-4, II-5, II-6, and II-7 carry a mutant allele of the gene encoding hexosaminidase B?

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Sandhoff disease is due to a mutation in a gene that encodes a protein
called hexosaminidase B. This disease has symptoms that are
similar to those of Tay-Sachs disease. Weakness begins in the first 6 months of life. Individuals exhibit early blindness and progressive mental and motor deterioration. The family in the pedigree shown below has three members with Sandhoff disease, indicated with black symbols.

I-1
1-2
П-1
П-2
П-3
П-4
П-5
П-6
П-7
III -1
III-2
Ш-3 Ш-4
Ш-5 Ш-6 Ш-7 Ш-8
A. Based on this pedigree, does this syndrome appear to
follow autosomal recessive, autosomal dominant, X-linked
recessive, or X-linked dominant inheritance? Explain
your reasoning.
B. What is the likelihood that II-1, II-2, II-3, II-4, II-5, II-6, and II-7
carry a mutant allele of the gene encoding hexosaminidase B?
Transcribed Image Text:I-1 1-2 П-1 П-2 П-3 П-4 П-5 П-6 П-7 III -1 III-2 Ш-3 Ш-4 Ш-5 Ш-6 Ш-7 Ш-8 A. Based on this pedigree, does this syndrome appear to follow autosomal recessive, autosomal dominant, X-linked recessive, or X-linked dominant inheritance? Explain your reasoning. B. What is the likelihood that II-1, II-2, II-3, II-4, II-5, II-6, and II-7 carry a mutant allele of the gene encoding hexosaminidase B?
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