I-1 1-2 П-1 П-2 П-3 П-4 П-5 П-6 П-7 III -1 III-2 Ш-3 Ш-4 Ш-5 Ш-6 Ш-7 Ш-8 A. Based on this pedigree, does this syndrome appear to follow autosomal recessive, autosomal dominant, X-linked recessive, or X-linked dominant inheritance? Explain your reasoning. B. What is the likelihood that II-1, II-2, II-3, II-4, II-5, II-6, and II-7 carry a mutant allele of the gene encoding hexosaminidase B?
I-1 1-2 П-1 П-2 П-3 П-4 П-5 П-6 П-7 III -1 III-2 Ш-3 Ш-4 Ш-5 Ш-6 Ш-7 Ш-8 A. Based on this pedigree, does this syndrome appear to follow autosomal recessive, autosomal dominant, X-linked recessive, or X-linked dominant inheritance? Explain your reasoning. B. What is the likelihood that II-1, II-2, II-3, II-4, II-5, II-6, and II-7 carry a mutant allele of the gene encoding hexosaminidase B?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Question
Sandhoff disease is due to a mutation in a gene that encodes a protein
called hexosaminidase B. This disease has symptoms that are
similar to those of Tay-Sachs disease. Weakness begins in the first 6 months of life. Individuals exhibit early blindness and progressive mental and motor deterioration. The family in the pedigree shown below has three members with Sandhoff disease, indicated with black symbols.

Transcribed Image Text:I-1
1-2
П-1
П-2
П-3
П-4
П-5
П-6
П-7
III -1
III-2
Ш-3 Ш-4
Ш-5 Ш-6 Ш-7 Ш-8
A. Based on this pedigree, does this syndrome appear to
follow autosomal recessive, autosomal dominant, X-linked
recessive, or X-linked dominant inheritance? Explain
your reasoning.
B. What is the likelihood that II-1, II-2, II-3, II-4, II-5, II-6, and II-7
carry a mutant allele of the gene encoding hexosaminidase B?
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