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Hypothalamus TRH Anterior pituitary TSH = Thyroid gland Thyroid hormones Stimulates Target cells -- Inhibits Panon Above is shown the pathway for secretion and feedback for thyroid hormones. Abbreviations: TRH, thyrotropin releasing hormone; TSH, thyroid stimulating hormone. A. As part of a routine genetic screen, you discover that a person has a defect in regulatory sequences for the receptor for the thyroid hormones (both T3 and T4). The receptors are functional, but are not expressed in hypothalamic cells. Their expression is normal in other tissues, such as the thyroid. Does this affect short- or long-loop feedback? Explain your answer.

Hypothalamus TRH Anterior pituitary TSH = Thyroid gland Thyroid hormones Stimulates Target cells -- Inhibits Panon Above is shown the pathway for secretion and feedback for thyroid hormones. Abbreviations: TRH, thyrotropin releasing hormone; TSH, thyroid stimulating hormone. A. As part of a routine genetic screen, you discover that a person has a defect in regulatory sequences for the receptor for the thyroid hormones (both T3 and T4). The receptors are functional, but are not expressed in hypothalamic cells. Their expression is normal in other tissues, such as the thyroid. Does this affect short- or long-loop feedback? Explain your answer.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Hypothalamus TRH Anterior pituitary TSH = Thyroid gland Thyroid hormones Stimulates Target cells -- Inhibits Panon Above is shown the pathway for secretion and feedback for thyroid hormones. Abbreviations: TRH, thyrotropin releasing hormone; TSH, thyroid stimulating hormone. A. As part of a routine genetic screen, you discover that a person has a defect in regulatory sequences for the receptor for the thyroid hormones (both T3 and T4). The receptors are functional, but are not expressed in hypothalamic cells. Their expression is normal in other tissues, such as the thyroid. Does this affect short- or long-loop feedback? Explain your answer.
Transcribed Image Text:Hypothalamus TRH Anterior pituitary TSH = Thyroid gland Thyroid hormones Stimulates Target cells -- Inhibits Panon Above is shown the pathway for secretion and feedback for thyroid hormones. Abbreviations: TRH, thyrotropin releasing hormone; TSH, thyroid stimulating hormone. A. As part of a routine genetic screen, you discover that a person has a defect in regulatory sequences for the receptor for the thyroid hormones (both T3 and T4). The receptors are functional, but are not expressed in hypothalamic cells. Their expression is normal in other tissues, such as the thyroid. Does this affect short- or long-loop feedback? Explain your answer.
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