Hypertrophic cardiomyopathy is caused by mutations in the β-myosin heavy chain gene. One common mutation involves a change of an arginine (Arg) to a glutamine (Gln) at position 403.     Using the genetic code shown above, what could the sequence of the mutant codon be?   a. CAA   b. CGA   c. CGG   d. CAC

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Hypertrophic cardiomyopathy is caused by mutations in the β-myosin heavy chain gene. One common mutation involves a change of an arginine (Arg) to a glutamine (Gln) at position 403.

 

 

Using the genetic code shown above, what could the sequence of the mutant codon be?

  a.

CAA

  b.

CGA

  c.

CGG

  d.

CAC

First position
(5' end)
U
с
A
G
Second position
U
с
Phe Ser
A
G
Tyr Cys
Phe Ser
Tyr Cys
Leu Ser Stop Stop
Leu Ser
Stop Trp
Leu Pro
His
Leu Pro
His
Leu Pro Gln
Leu
Ile
Ile
Ile
Met
Val
Val
Val
Val
Arg
Arg
Arg
Pro Gln Arg
Asn
Ser
Asn
Ser
Lys Arg
Lys Arg
Ala Asp Gly
Ala Asp Gly
Ala
Glu Gly
Ala
Glu
Gly
Thr
Thr
Thr
Thr
Third position
(3'end)
DUAUDU AUDU AUDUA
с
с
G
с
G
с
А
Transcribed Image Text:First position (5' end) U с A G Second position U с Phe Ser A G Tyr Cys Phe Ser Tyr Cys Leu Ser Stop Stop Leu Ser Stop Trp Leu Pro His Leu Pro His Leu Pro Gln Leu Ile Ile Ile Met Val Val Val Val Arg Arg Arg Pro Gln Arg Asn Ser Asn Ser Lys Arg Lys Arg Ala Asp Gly Ala Asp Gly Ala Glu Gly Ala Glu Gly Thr Thr Thr Thr Third position (3'end) DUAUDU AUDU AUDUA с с G с G с А
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