Hydrogen bonding between amide molecules may be shown as in O CH-C-N-H --- H-N-C-CH, H H CH3-C-N-H CH3-C-N-H O CH3-C-N-H --- CH-C-N-H H H CH3 CH3-C-N-H H H-N C=0

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## Hydrogen Bonding Between Amide Molecules

Hydrogen bonding between amide molecules may be shown as in the following structures. Please review each possibility and determine which one correctly demonstrates the hydrogen bonding:

### Option A:

**Structure:**
```
CH3-C=O
     |
     N-H --- H-N-C-CH3
     |           |
     H           H
```

### Option B:

**Structure:**
```
CH3-C=O        O=C-CH3
     |            |
     N-H --- H    N-H
     |           |
     H          H
```

### Option C:

**Structure:**
```
CH3-C=O        O=O         O=C-CH3
     |           |          |
     N-H --- H   N-H        N-H
     |           |          |
     H           H          H
```

### Option D:

**Structure:**
```
CH3-C=O          O=         O
     |           |          |
     N-H --- H   N-H        N-H
     |           |          |
     H          H           H
```

**Explanation of Concepts:**

- **Hydrogen Bonding:** In the context of amides, hydrogen bonds usually form between the hydrogen atom attached to the nitrogen (N-H) of one amide group and the oxygen atom (C=O) of another amide group. This is crucial for the secondary structure of proteins and other biomolecules.

**Diagrams:**

- Each option represents a possible way that hydrogen bonds might form.
- Typically, the most common hydrogen bonding in amides occurs between the carbonyl oxygen (C=O) and the amide hydrogen (N-H).

Evaluate each option carefully to recognize the structure that accurately portrays the hydrogen bonding mechanism in amide molecules.
Transcribed Image Text:## Hydrogen Bonding Between Amide Molecules Hydrogen bonding between amide molecules may be shown as in the following structures. Please review each possibility and determine which one correctly demonstrates the hydrogen bonding: ### Option A: **Structure:** ``` CH3-C=O | N-H --- H-N-C-CH3 | | H H ``` ### Option B: **Structure:** ``` CH3-C=O O=C-CH3 | | N-H --- H N-H | | H H ``` ### Option C: **Structure:** ``` CH3-C=O O=O O=C-CH3 | | | N-H --- H N-H N-H | | | H H H ``` ### Option D: **Structure:** ``` CH3-C=O O= O | | | N-H --- H N-H N-H | | | H H H ``` **Explanation of Concepts:** - **Hydrogen Bonding:** In the context of amides, hydrogen bonds usually form between the hydrogen atom attached to the nitrogen (N-H) of one amide group and the oxygen atom (C=O) of another amide group. This is crucial for the secondary structure of proteins and other biomolecules. **Diagrams:** - Each option represents a possible way that hydrogen bonds might form. - Typically, the most common hydrogen bonding in amides occurs between the carbonyl oxygen (C=O) and the amide hydrogen (N-H). Evaluate each option carefully to recognize the structure that accurately portrays the hydrogen bonding mechanism in amide molecules.
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