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How would loss of the retromer coat most likely affect cargo shuttling between the Golgi apparatus and early endosome? M6P receptor would not recycle back to the Golgi Cargo shuttling would be unaffected Vesicles would not target to the endosome O M6P receptor would not bind cargo Cargo would not be released from the M6P receptor

How would loss of the retromer coat most likely affect cargo shuttling between the Golgi apparatus and early endosome? M6P receptor would not recycle back to the Golgi Cargo shuttling would be unaffected Vesicles would not target to the endosome O M6P receptor would not bind cargo Cargo would not be released from the M6P receptor

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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How would loss of the retromer coat most likely affect cargo shuttling between the Golgi apparatus and early endosome? M6P receptor would not recycle back to the Golgi Cargo shuttling would be unaffected Vesicles would not target to the endosome M6P receptor would not bind cargo Cargo would not be released from the M6P receptor
Transcribed Image Text:How would loss of the retromer coat most likely affect cargo shuttling between the Golgi apparatus and early endosome? M6P receptor would not recycle back to the Golgi Cargo shuttling would be unaffected Vesicles would not target to the endosome M6P receptor would not bind cargo Cargo would not be released from the M6P receptor
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Retromer is the protein complex in the periphery of the membrane which regulates various trafficking processes within the endolysosomal system. The absence of Vps35 which is a sub-unit of Retromer will cause the reduction in the lysosomal hydrolases. 

Now, this processing of the lysosomal hydrolases is dependent on the trafficking of the cation-independent M6P (Mannose-6-phosphate).

Thus. Retromer is important and responsible for the retrograde trafficking of M6P which necessary for the maturation of the lysosomal hydrolases and the function of the lysosomes.

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