How does the sarcoplasmic reticulum know when to release Calcium ions instead of continuously pump them into itself?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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How does the sarcoplasmic reticulum know when to release Calcium ions instead of continuously pump them into itself?

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Neuromuscular impulse transmission:

Nervous stimulation results in spreading of action potential in presynaptic motor neuron. This causes opening of voltage gated sodium channels on presynaptic membrane,  sodium ions ( Na+) rushes into the axon terminal and causes depolarisation of the membrane. 

  • This results in opening of voltage gated calcium channels .

Axon terminal houses synaptic vesicles containing neurotransmitter (acetylcholine). 

  • Calcium( Ca++) binds to these vesicles and induce exocytosis of the vesicles , this releases acetylcholine into synaptic cleft.
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