2. Circle the compound that would have the lowest energy at its most stable conformation and box the compound that would have the highest energy at its most stable conformation. 호호호호

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### Understanding Conformational Stability

**Objective:**
Determine which compound has the lowest energy at its most stable conformation and which one has the highest energy.

**Question:**
2. Circle the compound that would have the lowest energy at its most stable conformation and box the compound that would have the highest energy at its most stable conformation.

**Structural Diagrams:**
Below are four structural diagrams of cyclohexane derivatives. Each structure exhibits different substituent positions, either axial or equatorial.

1. **First Structure:**
   - One methyl group in the equatorial position.
   - Another methyl group in the axial position.
   - A third methyl group in the axial position, opposite the first.

2. **Second Structure:**
   - One methyl group in the equatorial position.
   - Another methyl group in the equatorial position.
   - A third methyl group in the axial position.

3. **Third Structure:**
   - One methyl group in the equatorial position.
   - Another methyl group in the axial position.
   - A third methyl group in the equatorial position, opposite the first.

4. **Fourth Structure:**
   - One methyl group in the axial position.
   - Another methyl group in the axial position, opposite the first.
   - A third methyl group in the axial position.

### Detailed Analysis:

- In the **first structure**, two large groups are in the unfavorable axial positions, leading to high steric strain.
- In the **second structure**, two large groups take the more favorable equatorial positions, reducing steric strain.
- In the **third structure**, there is less steric hindrance due to the axial-equatorial positioning.
- In the **fourth structure**, three large groups are in axial positions, significantly increasing steric strain and energy.

### Conclusion:

- **Circle** the **second structure** as it has the lowest energy conformation due to minimized steric hindrance.
- **Box** the **fourth structure** as it has the highest energy conformation due to maximum steric strain.
Transcribed Image Text:### Understanding Conformational Stability **Objective:** Determine which compound has the lowest energy at its most stable conformation and which one has the highest energy. **Question:** 2. Circle the compound that would have the lowest energy at its most stable conformation and box the compound that would have the highest energy at its most stable conformation. **Structural Diagrams:** Below are four structural diagrams of cyclohexane derivatives. Each structure exhibits different substituent positions, either axial or equatorial. 1. **First Structure:** - One methyl group in the equatorial position. - Another methyl group in the axial position. - A third methyl group in the axial position, opposite the first. 2. **Second Structure:** - One methyl group in the equatorial position. - Another methyl group in the equatorial position. - A third methyl group in the axial position. 3. **Third Structure:** - One methyl group in the equatorial position. - Another methyl group in the axial position. - A third methyl group in the equatorial position, opposite the first. 4. **Fourth Structure:** - One methyl group in the axial position. - Another methyl group in the axial position, opposite the first. - A third methyl group in the axial position. ### Detailed Analysis: - In the **first structure**, two large groups are in the unfavorable axial positions, leading to high steric strain. - In the **second structure**, two large groups take the more favorable equatorial positions, reducing steric strain. - In the **third structure**, there is less steric hindrance due to the axial-equatorial positioning. - In the **fourth structure**, three large groups are in axial positions, significantly increasing steric strain and energy. ### Conclusion: - **Circle** the **second structure** as it has the lowest energy conformation due to minimized steric hindrance. - **Box** the **fourth structure** as it has the highest energy conformation due to maximum steric strain.
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