Homozygous recessives from inbreeding 2 one Ala one A/A 2 3 4 A/A A/a Ala A/A II 1 2 A/- AF A- A- Ala 3 4 5 6 A/a IV 1 2 3 45 A- ala A- ala A- The FIGURE 2-19 Pedigree of a rare recessive phenotype determined by a recessive allele a. Gene symbols are normally not included in pedigree charts, but genotypes are inserted here for reference. Persons Il-1 and I-5 marry into the family; they are assumed to be normal because the heritable condition under scrutiny is rare. Note also that it is not possible to be certain of the genotype in some persons with normal phenotype; Such persons are indicated by A/-. Persons III-5 and I-6, who generate the recessives in generation IV, are first cousins. They both obtain their recessive allele from a grandparent, either l-1 or l-2. unrelate sometir heteroz Figure 2 gotes fa heteroz two coL ancesto the rare run a hi relative people Som Cystic f rules as

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In Figure 2-19, assume that the pedigree is for mice, in
which any chosen cross can be made. If you bred IV-1
with IV-3, what is the probability that the first baby will
show the recessive phenotype?

Homozygous recessives
from inbreeding
2
one Ala one A/A
2
3
4
A/A A/a
Ala A/A
II
1 2
A/- AF A- A- Ala
3
4 5
6
A/a
IV
1 2 3 45
A- ala A- ala A-
The
FIGURE 2-19 Pedigree of a rare
recessive phenotype determined by a
recessive allele a. Gene symbols are
normally not included in pedigree charts,
but genotypes are inserted here for
reference. Persons Il-1 and I-5 marry into
the family; they are assumed to be normal
because the heritable condition under
scrutiny is rare. Note also that it is not
possible to be certain of the genotype in
some persons with normal phenotype;
Such persons are indicated by A/-.
Persons III-5 and I-6, who generate the
recessives in generation IV, are first
cousins. They both obtain their recessive
allele from a grandparent, either l-1 or l-2.
unrelate
sometir
heteroz
Figure 2
gotes fa
heteroz
two coL
ancesto
the rare
run a hi
relative
people
Som
Cystic f
rules as
Transcribed Image Text:Homozygous recessives from inbreeding 2 one Ala one A/A 2 3 4 A/A A/a Ala A/A II 1 2 A/- AF A- A- Ala 3 4 5 6 A/a IV 1 2 3 45 A- ala A- ala A- The FIGURE 2-19 Pedigree of a rare recessive phenotype determined by a recessive allele a. Gene symbols are normally not included in pedigree charts, but genotypes are inserted here for reference. Persons Il-1 and I-5 marry into the family; they are assumed to be normal because the heritable condition under scrutiny is rare. Note also that it is not possible to be certain of the genotype in some persons with normal phenotype; Such persons are indicated by A/-. Persons III-5 and I-6, who generate the recessives in generation IV, are first cousins. They both obtain their recessive allele from a grandparent, either l-1 or l-2. unrelate sometir heteroz Figure 2 gotes fa heteroz two coL ancesto the rare run a hi relative people Som Cystic f rules as
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