HO 1) 1 eq. PhMgBr 2) H2O

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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The image depicts a chemical reaction involving a cyclopentanone ring with one hydroxyl group (OH) and one carbonyl group (C=O) on adjacent carbons.

**Reaction Steps:**

1. **Reactant:** The starting compound is a cyclopentanone derivative.
2. **Reagent 1:** 1 equivalent of phenylmagnesium bromide (PhMgBr), a Grignard reagent, is added. This reagent typically reacts with carbonyl groups.
3. **Reagent 2:** Water (H₂O) is added in a subsequent step to quench the reaction.

**Explanation:**

- The Grignard reagent (PhMgBr) adds to the carbonyl group of the cyclopentanone. The carbon atom of the carbonyl group becomes a new stereocenter, forming a secondary alcohol after water is added to protonate the alkoxide intermediate.
- This reaction is an example of a nucleophilic addition where the Grignard reagent acts as a nucleophile and the carbonyl carbon as an electrophile.

This is a classic organic reaction used in synthesizing alcohols from ketones or aldehydes.
Transcribed Image Text:The image depicts a chemical reaction involving a cyclopentanone ring with one hydroxyl group (OH) and one carbonyl group (C=O) on adjacent carbons. **Reaction Steps:** 1. **Reactant:** The starting compound is a cyclopentanone derivative. 2. **Reagent 1:** 1 equivalent of phenylmagnesium bromide (PhMgBr), a Grignard reagent, is added. This reagent typically reacts with carbonyl groups. 3. **Reagent 2:** Water (H₂O) is added in a subsequent step to quench the reaction. **Explanation:** - The Grignard reagent (PhMgBr) adds to the carbonyl group of the cyclopentanone. The carbon atom of the carbonyl group becomes a new stereocenter, forming a secondary alcohol after water is added to protonate the alkoxide intermediate. - This reaction is an example of a nucleophilic addition where the Grignard reagent acts as a nucleophile and the carbonyl carbon as an electrophile. This is a classic organic reaction used in synthesizing alcohols from ketones or aldehydes.
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