HN. Bupropion 8) a) An acidic drug has a pka of 3.6. Is this drug likely to be soluble if formulated as an effervescent tablet buffered at pH 6.5 when the buffers dissolve? Explain your answer using equations and include calculations showing the percentage of the drug which is ionised.

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HN.
Bupropion
8) a) An acidic drug has a pka of 3.6. Is this drug likely to be soluble if formulated as an effervescent
tablet buffered at pH 6.5 when the buffers dissolve? Explain your answer using equations and include
calculations showing the percentage of the drug which is ionised.
9) A 1.0 L buffer solution is prepared and has a final concentration of 0.6 M ammonium chloride and
0.40 M ammonia. The pKa of ammonium chloride is 9.12.
a) Calculate the pH of the buffer solution.
b) If 100 ml of a 1M HCl solution was added calculate the new pH.
Transcribed Image Text:HN. Bupropion 8) a) An acidic drug has a pka of 3.6. Is this drug likely to be soluble if formulated as an effervescent tablet buffered at pH 6.5 when the buffers dissolve? Explain your answer using equations and include calculations showing the percentage of the drug which is ionised. 9) A 1.0 L buffer solution is prepared and has a final concentration of 0.6 M ammonium chloride and 0.40 M ammonia. The pKa of ammonium chloride is 9.12. a) Calculate the pH of the buffer solution. b) If 100 ml of a 1M HCl solution was added calculate the new pH.
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