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Hidradenitis suppurativa is a chronic hair follicular occlusive disease that is believed to be initiated by abnormal keratinocyte differentiation and failure of keratinocytes to shed from which of the following areas of the skin?

Hidradenitis suppurativa is a chronic hair follicular occlusive disease that is believed to be initiated by abnormal keratinocyte differentiation and failure of keratinocytes to shed from which of the following areas of the skin?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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### Educational Content: Histological Structures in Hidradenitis Suppurativa **Title: Understanding Keratinocyte Abnormalities in Hidradenitis Suppurativa** Hidradenitis suppurativa is a chronic skin condition marked by follicular occlusion. This disease is linked to abnormal keratinocyte differentiation and the failure of keratinocytes to shed from specific skin areas. Below are histological images labeled A to E, each depicting different components involved in this process. #### Image Explanation: - **Image A:** - Displays a histological section of a hair follicle. The labeled components include: - **H**: Hair shaft - **D**: Hair follicle duct - The surrounding tissue may show signs of inflammation or occlusion, characteristic of the condition. - **Image B:** - Shows a close-up of the epidermal layer. Notice the wavy appearance of the outer skin layers and the beginning of keratinocyte differentiation issues. - **Image C:** - Highlights a coiled tubular structure, possibly a sweat gland. The label **D** points to the duct, and **S** refers to secretory portions. - **Image D:** - Represents a detailed section of a hair follicle labeled with: - **CTS**: Connective tissue sheath - **ERS**: External root sheath - **IRS**: Internal root sheath - **CO**: Cuticle - **M**: Matrix - **CU**: Cortex - This image provides insight into the structural components that may be involved in keratinocyte occlusion. - **Image E:** - Depicts elongated structures, possibly sebaceous glands or hair follicles. The label **D** indicates a duct, and **S** points out secretory cells. These images serve as a critical tool for understanding the pathological changes in skin structures, especially concerning keratinocyte behavior in hidradenitis suppurativa. Recognizing these changes can aid in the diagnosis and the development of targeted treatments.
Transcribed Image Text:### Educational Content: Histological Structures in Hidradenitis Suppurativa **Title: Understanding Keratinocyte Abnormalities in Hidradenitis Suppurativa** Hidradenitis suppurativa is a chronic skin condition marked by follicular occlusion. This disease is linked to abnormal keratinocyte differentiation and the failure of keratinocytes to shed from specific skin areas. Below are histological images labeled A to E, each depicting different components involved in this process. #### Image Explanation: - **Image A:** - Displays a histological section of a hair follicle. The labeled components include: - **H**: Hair shaft - **D**: Hair follicle duct - The surrounding tissue may show signs of inflammation or occlusion, characteristic of the condition. - **Image B:** - Shows a close-up of the epidermal layer. Notice the wavy appearance of the outer skin layers and the beginning of keratinocyte differentiation issues. - **Image C:** - Highlights a coiled tubular structure, possibly a sweat gland. The label **D** points to the duct, and **S** refers to secretory portions. - **Image D:** - Represents a detailed section of a hair follicle labeled with: - **CTS**: Connective tissue sheath - **ERS**: External root sheath - **IRS**: Internal root sheath - **CO**: Cuticle - **M**: Matrix - **CU**: Cortex - This image provides insight into the structural components that may be involved in keratinocyte occlusion. - **Image E:** - Depicts elongated structures, possibly sebaceous glands or hair follicles. The label **D** indicates a duct, and **S** points out secretory cells. These images serve as a critical tool for understanding the pathological changes in skin structures, especially concerning keratinocyte behavior in hidradenitis suppurativa. Recognizing these changes can aid in the diagnosis and the development of targeted treatments.
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