hat will happen to CRH secretion in a patient given very high doses of a synthetic glucocorticoid (prednisone) that is 5-times more potent that cortisol? Why?
hat will happen to CRH secretion in a patient given very high doses of a synthetic glucocorticoid (prednisone) that is 5-times more potent that cortisol? Why?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
Question 1: What will happen to CRH secretion in a patient given very high doses of a synthetic glucocorticoid (prednisone) that is 5-times more potent that cortisol? Why?
Question 2: What will happen to plasma cortisol concentration and the size of the adrenal glands in a patient given very high doses of a synthetic glucocorticoid (prednisone) that is 5-times more potent that cortisol? Why?
Question 3: If a patient has been taking high doses of prednisone for a year, can the prednisone be abruptly stopped?
Transcribed Image Text:Question 1: What will happen to CRH secretion in a patient
given very high doses of a synthetic glucocorticoid
(prednisone) that is 5-times more potent that cortisol? Why?
Question 2: What will happen to plasma cortisol
concentration and the size of the adrenal glands in a patient
given very high doses of a synthetic glucocorticoid
(prednisone) that is 5-times more potent that cortisol? Why?
Question 3: (extra credit): If a patient has been taking high
doses of prednisone for a year, can the prednisone be abruptly
stopped?
Transcribed Image Text:Neural inputs (stress)
Hypothalamus
↑ CRH secretion
1 Plasma CRH
(in hypothalamo-hypophyseal portal vessels)
Anterior pituitary
↑ ACTH secretion
↑ Plasma ACTH
Adrenal cortex
↑ Cortisol secretion
↑ Plasma cortisol
Target cells for cortisol
Respond to increased cortisol
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