Happened? (There are at least expla 2. Drugs with names that end in "-mab" consist of anti- bodies, and the research that yields these medications typically begins with mice. A mouse is injected with a molecule of interest: a human cytokine, for example, or a receptor implicated in cancer. The resulting antibody- mediated response produces a set of antibodies that recognize different parts of the molecule. B cells are harvested from the mouse's spleen, fused with cancerous B cells, and then cloned-isolated and cultivated sepa- rately. Each of the resulting cell lines produces identical antibodies that bind to one part of the injected molecule. These antibodies are called monoclonal antibodies, and they can be purified and studied for use as drugs. Monoclonal antibodies can be effective drugs, but only in the immediate term. Antibodies produced by one's own immune system can last up to about six months in the bloodstream, but mono- clonals delivered in passive immuniza- tion often last for less than a week. Why the difference? A

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
icon
Concept explainers
Question
Question 2
ls
happened? (There are at least the expan
2. Drugs with names that end in "-mab" consist of anti-
bodies, and the research that yields these medications
typically begins with mice. A mouse is injected with a
molecule of interest: a human cytokine, for example, or
a receptor implicated in cancer. The resulting antibody-
mediated response produces a set of antibodies that
recognize different parts of the molecule. B cells are
harvested from the mouse's spleen, fused with cancerous
B cells, and then cloned-isolated and cultivated sepa-
rately. Each of the resulting cell lines produces identical
antibodies that bind to one part of the injected molecule.
These antibodies are called monoclonal antibodies, and
they can be purified and studied for use as drugs.
Monoclonal antibodies can be effective drugs, but
only in the immediate term. Antibodies produced by
one's own immune system can last up to about six
months in the bloodstream, but mono-
clonals delivered in passive immuniza-
tion often last for less than a week. Why
the difference?
A
Transcribed Image Text:ls happened? (There are at least the expan 2. Drugs with names that end in "-mab" consist of anti- bodies, and the research that yields these medications typically begins with mice. A mouse is injected with a molecule of interest: a human cytokine, for example, or a receptor implicated in cancer. The resulting antibody- mediated response produces a set of antibodies that recognize different parts of the molecule. B cells are harvested from the mouse's spleen, fused with cancerous B cells, and then cloned-isolated and cultivated sepa- rately. Each of the resulting cell lines produces identical antibodies that bind to one part of the injected molecule. These antibodies are called monoclonal antibodies, and they can be purified and studied for use as drugs. Monoclonal antibodies can be effective drugs, but only in the immediate term. Antibodies produced by one's own immune system can last up to about six months in the bloodstream, but mono- clonals delivered in passive immuniza- tion often last for less than a week. Why the difference? A
Expert Solution
steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Bacterial genomics
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education