Happened? (There are at least expla 2. Drugs with names that end in "-mab" consist of anti- bodies, and the research that yields these medications typically begins with mice. A mouse is injected with a molecule of interest: a human cytokine, for example, or a receptor implicated in cancer. The resulting antibody- mediated response produces a set of antibodies that recognize different parts of the molecule. B cells are harvested from the mouse's spleen, fused with cancerous B cells, and then cloned-isolated and cultivated sepa- rately. Each of the resulting cell lines produces identical antibodies that bind to one part of the injected molecule. These antibodies are called monoclonal antibodies, and they can be purified and studied for use as drugs. Monoclonal antibodies can be effective drugs, but only in the immediate term. Antibodies produced by one's own immune system can last up to about six months in the bloodstream, but mono- clonals delivered in passive immuniza- tion often last for less than a week. Why the difference? A
Bacterial Genomics
The study of the morphological, physiological, and evolutionary aspects of the bacterial genome is referred to as bacterial genomics. This subdisciplinary field aids in understanding how genes are assembled into genomes. Further, bacterial or microbial genomics has helped researchers in understanding the pathogenicity of bacteria and other microbes.
Transformation Experiment in Bacteria
In the discovery of genetic material, the experiment conducted by Frederick Griffith on Streptococcus pneumonia proved to be a stepping stone.
Plasmids and Vectors
The DNA molecule that exists in a circular shape and is smaller in size which is capable of its replication is called Plasmids. In other words, it is called extra-chromosomal plasmid DNA. Vectors are the molecule which is capable of carrying genetic material which can be transferred into another cell and further carry out replication and expression. Plasmids can act as vectors.
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