Hair color is determined in Labrador retrievers by alleles at the B and E loci. A dominant allele B encodes black pigment, whereas a recessive allele b encodes brown pigment. Alleles at a second locus affect the deposition of the pigment in the shaft of the hair; dominant allele E allows dark pigment (black or brown) to be deposited, whereas recessive allele e prevents the deposition of dark pigment, causing the hair to be yellow. What type of gene interaction does this represent?

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### Understanding Non-Mendelian Patterns of Inheritance: Epistasis in Labrador Retrievers

**LO19 Analyze a cross and identify non-Mendelian pattern of inheritance in non-allelic genes (normal interaction vs epistasis)**

#### Genetic Determination of Hair Color in Labrador Retrievers

Hair color in Labrador retrievers is determined by alleles at two loci: the B locus and the E locus.
- The **B locus** contains alleles that encode different pigments:
  - **B (dominant allele)**: Encodes black pigment.
  - **b (recessive allele)**: Encodes brown pigment.

- The **E locus** affects the deposition of the pigment in the hair shaft:
  - **E (dominant allele)**: Allows the deposition of dark pigment (either black or brown), resulting in a dark-colored coat.
  - **e (recessive allele)**: Prevents the deposition of dark pigment, causing the hair to be yellow regardless of the alleles present at the B locus.

#### Question: What Type of Gene Interaction Does This Represent?

Below are the options for the types of gene interaction:

- **duplicate recessive epistasis**
- **normal non-allelic gene interaction**
- **recessive epistasis**
- **dominant epistasis**
- **normal allelic gene interaction**

In this context, the presence of the recessive allele (**e**) at the E locus prevents the deposition of dark pigment regardless of the alleles present at the B locus, leading to yellow hair. This represents a specific type of gene interaction known as **recessive epistasis** where the recessive allele at one locus (E) masks the expression of alleles at a second locus (B).

#### Correct Answer:
- **Recessive epistasis**

By understanding these genetic interactions, we can predict the phenotypes of Labrador retriever offspring based on their genotypes at the B and E loci. This type of genetic analysis provides insights into more complex patterns of inheritance that go beyond Mendelian inheritance.
Transcribed Image Text:### Understanding Non-Mendelian Patterns of Inheritance: Epistasis in Labrador Retrievers **LO19 Analyze a cross and identify non-Mendelian pattern of inheritance in non-allelic genes (normal interaction vs epistasis)** #### Genetic Determination of Hair Color in Labrador Retrievers Hair color in Labrador retrievers is determined by alleles at two loci: the B locus and the E locus. - The **B locus** contains alleles that encode different pigments: - **B (dominant allele)**: Encodes black pigment. - **b (recessive allele)**: Encodes brown pigment. - The **E locus** affects the deposition of the pigment in the hair shaft: - **E (dominant allele)**: Allows the deposition of dark pigment (either black or brown), resulting in a dark-colored coat. - **e (recessive allele)**: Prevents the deposition of dark pigment, causing the hair to be yellow regardless of the alleles present at the B locus. #### Question: What Type of Gene Interaction Does This Represent? Below are the options for the types of gene interaction: - **duplicate recessive epistasis** - **normal non-allelic gene interaction** - **recessive epistasis** - **dominant epistasis** - **normal allelic gene interaction** In this context, the presence of the recessive allele (**e**) at the E locus prevents the deposition of dark pigment regardless of the alleles present at the B locus, leading to yellow hair. This represents a specific type of gene interaction known as **recessive epistasis** where the recessive allele at one locus (E) masks the expression of alleles at a second locus (B). #### Correct Answer: - **Recessive epistasis** By understanding these genetic interactions, we can predict the phenotypes of Labrador retriever offspring based on their genotypes at the B and E loci. This type of genetic analysis provides insights into more complex patterns of inheritance that go beyond Mendelian inheritance.
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