6 Based on the EC50 values for the compounds below, explain why rigid analogs may notalways be more potent or efficacious than the more flexible analog.H HRR"H,HEC50 = 100 nMEC50 = 10 nMEC50 = 1000 nM

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Answered: H H .R .R C50 = 100 nM EC50 = 10 nM…

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H H .R .R C50 = 100 nM EC50 = 10 nM EC50 = 1000 nM %3D

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

Based on the EC50 values for the compounds below, explain why rigid analogs may not
always be more potent or efficacious than the more flexible analog.
H H
R
R
"H,
H
EC50 = 100 nM
EC50 = 10 nM
EC50 = 1000 nM

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