Given the following substrates and enzymes, provide a Scheme to the tri-deuterated 5,10- methylenetetrahydrofolate A. There is no need to redraw the structures, simply use the number the structures and indicate which enzymes are used at the appropriate place in the Scheme. Do deuterated formaldehyde and deuterated tetrahydrofolate in your Scheme.

Biochemistry
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ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter18: Glycolysis
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Problem 23P: Examine the ActiveModel for alcohol dehydrogenase and describe the structure and function of the...
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Given the following substrates and enzymes, provide a Scheme to the tri-deuterated 5,10-
methylenetetrahydrofolate A. There is no need to redraw the structures, simply use the numbers below
the structures and indicate which enzymes are used at the appropriate place in the Scheme. Do show
deuterated formaldehyde and deuterated tetrahydrofolate in your Scheme.
H2N N.
HN.
N.
D.
CO,H
čo,H
A
Available substrates and enzymes: Dihydrofolate reductase (DHFR), Serine hydroxymethylase (SHMA)
H.
H,NLCO,H
H2N N.
но.
HN.
'N'
HO,
D
Me
HN
.co,H
D.
čO,H
3
NH2
N'
R = rest of NADH
IZ
2.
I,
Z-R
Transcribed Image Text:Given the following substrates and enzymes, provide a Scheme to the tri-deuterated 5,10- methylenetetrahydrofolate A. There is no need to redraw the structures, simply use the numbers below the structures and indicate which enzymes are used at the appropriate place in the Scheme. Do show deuterated formaldehyde and deuterated tetrahydrofolate in your Scheme. H2N N. HN. N. D. CO,H čo,H A Available substrates and enzymes: Dihydrofolate reductase (DHFR), Serine hydroxymethylase (SHMA) H. H,NLCO,H H2N N. но. HN. 'N' HO, D Me HN .co,H D. čO,H 3 NH2 N' R = rest of NADH IZ 2. I, Z-R
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