3 e）Give the product ### Chemical Reaction SequenceIn this multi-step chemical reaction sequence, an epoxide is first reacted with a Grignard reagent followed by a hydrolysis step, and then further reacted with a phosphoryl chloride reagent in the presence of pyridine. #### Steps and Reagents:1. **Epoxide Opening:** - Starting Material: Epoxide (represented by a three-membered ring containing an oxygen atom). - Reagent: Phenylmagnesium bromide (C\(_6\)H\(_5\)MgBr). - Reaction: The Grignard reagent attacks the epoxide ring, initiating an opening to form an alkoxide intermediate.2. **Hydrolysis:** - Reagent: H\(_3\)O\(^+\) (hydronium ion). - Reaction: Protonation of the alkoxide to yield an alcohol (designated as compound A).3. **Formation of Phosphate Ester:** - Reagent: Phosphoryl chloride (POCl\(_3\)) in the presence of pyridine. - Reaction: Transformation of compound A into compound B, involving the incorporation of the phosphate group facilitated by pyridine as a base.These reactions illustrate principles of organic synthesis, including nucleophilic attack, ring opening, and ester formation.### Diagram Explanation- **Structure Labels:** - **Epoxide** is depicted as a triangle with an oxygen atom at one vertex, indicating the three-membered cyclic ether. - **Aromatic Grignard Reagent** consists of a benzene ring bonded to magnesium bromide.- **Product Progression:** - **Compound A**: An intermediate product after opening the epoxide and hydrolysis. - **Compound B**: Final product after reaction with phosphoryl chloride, featuring a phosphate ester group as indicated by the pentavalent phosphorus atom bonded to oxygen and chlorine atoms.This sequence highlights classical reaction types used in organic synthesis and transformation processes.

The highly reactive epoxide ring is opened in the presence of a nucleophile. It gives a biomolecular…

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Give the product

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

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3 e）Give the product

### Chemical Reaction Sequence

In this multi-step chemical reaction sequence, an epoxide is first reacted with a Grignard reagent followed by a hydrolysis step, and then further reacted with a phosphoryl chloride reagent in the presence of pyridine.

#### Steps and Reagents:

1. **Epoxide Opening:**
- Starting Material: Epoxide (represented by a three-membered ring containing an oxygen atom).
- Reagent: Phenylmagnesium bromide (C\(_6\)H\(_5\)MgBr).
- Reaction: The Grignard reagent attacks the epoxide ring, initiating an opening to form an alkoxide intermediate.

2. **Hydrolysis:**
- Reagent: H\(_3\)O\(^+\) (hydronium ion).
- Reaction: Protonation of the alkoxide to yield an alcohol (designated as compound A).

3. **Formation of Phosphate Ester:**
- Reagent: Phosphoryl chloride (POCl\(_3\)) in the presence of pyridine.
- Reaction: Transformation of compound A into compound B, involving the incorporation of the phosphate group facilitated by pyridine as a base.

These reactions illustrate principles of organic synthesis, including nucleophilic attack, ring opening, and ester formation.

### Diagram Explanation

- **Structure Labels:**
- **Epoxide** is depicted as a triangle with an oxygen atom at one vertex, indicating the three-membered cyclic ether.
- **Aromatic Grignard Reagent** consists of a benzene ring bonded to magnesium bromide.

- **Product Progression:**
- **Compound A**: An intermediate product after opening the epoxide and hydrolysis.
- **Compound B**: Final product after reaction with phosphoryl chloride, featuring a phosphate ester group as indicated by the pentavalent phosphorus atom bonded to oxygen and chlorine atoms.

This sequence highlights classical reaction types used in organic synthesis and transformation processes.

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