Give the major product for the following E2 reaction considering all possible conformers. CH3 CHICH-CH-CHỊCH Br CH-CH₂CH₂ -CH=CHCHCHỊCH: CH3 -CH₂-CH₂-C-CHCH3 CH3 -CH₂-CH=C- -CH₂CH3 OCH₁

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**E2 Reaction and Major Product Analysis**

**Question:**
Determine the major product of the following E2 reaction, taking into account all possible conformers.

**Reaction Details:**
- **Reactant:** A molecule consisting of a benzene ring attached to a CH\(_2\)-CHBr-CH(CH\(_3\))-CH\(_2\)CH\(_3\) structure.
- **Reagent:** Methoxide ion (\(OCH_3^-\)).

**Potential Products:**
1. **Option 1:**
   - Structure: \(\text{Benzene ring}-\text{CH}=\text{CH}-\text{CH}_2-\text{CH}_2\text{CH}_3\)
2. **Option 2:**
   - Structure: \(\text{Benzene ring}-\text{CH}_2- \text{CH}_2= \text{C}(CH_3)\text{CH}_3\)
3. **Option 3:**
   - Structure: \(\text{Benzene ring}-\text{CH}_2- \text{CH}=\text{CH}-\text{CH}_2 \text{CH}_3\)

**Analysis:**
- Evaluate the stability of the alkenes formed.
- Consider the Zaitsev's rule, which predicts the most substituted alkene as the major product in an E2 reaction.
- Analyze the leaving group's alignment and the proton's availability for abstraction.

**Conclusion:**
Select the most stable alkene product based on the reaction conditions and possible conformers.
Transcribed Image Text:**E2 Reaction and Major Product Analysis** **Question:** Determine the major product of the following E2 reaction, taking into account all possible conformers. **Reaction Details:** - **Reactant:** A molecule consisting of a benzene ring attached to a CH\(_2\)-CHBr-CH(CH\(_3\))-CH\(_2\)CH\(_3\) structure. - **Reagent:** Methoxide ion (\(OCH_3^-\)). **Potential Products:** 1. **Option 1:** - Structure: \(\text{Benzene ring}-\text{CH}=\text{CH}-\text{CH}_2-\text{CH}_2\text{CH}_3\) 2. **Option 2:** - Structure: \(\text{Benzene ring}-\text{CH}_2- \text{CH}_2= \text{C}(CH_3)\text{CH}_3\) 3. **Option 3:** - Structure: \(\text{Benzene ring}-\text{CH}_2- \text{CH}=\text{CH}-\text{CH}_2 \text{CH}_3\) **Analysis:** - Evaluate the stability of the alkenes formed. - Consider the Zaitsev's rule, which predicts the most substituted alkene as the major product in an E2 reaction. - Analyze the leaving group's alignment and the proton's availability for abstraction. **Conclusion:** Select the most stable alkene product based on the reaction conditions and possible conformers.
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