Give all questions answers with explanation please

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Give all questions answers with explanation please
7. The following carboxylic acid derivatives are used for de novo synthesis of the amides
found in peptides. The pKa values of the protonated leaving groups are shown.
NO2
N=N
HO
HO-N.
HO
HS
pka = 7.1
pka = 6.0
pka = 10.0
pka = 4.3
%3D
NO2
N=N
PNP
Osu
2-SHPY
HOBI
a. Rank the derivatives from most reactive (1) to least reactive (4) (under the structures
above, or using the abbreviations) as carboxylic acid derivatives. Explain your
reasoning briefly.
b. What carboxylic acid derivative is more reactive than all of these derivatives? Explain
your answer.
Transcribed Image Text:7. The following carboxylic acid derivatives are used for de novo synthesis of the amides found in peptides. The pKa values of the protonated leaving groups are shown. NO2 N=N HO HO-N. HO HS pka = 7.1 pka = 6.0 pka = 10.0 pka = 4.3 %3D NO2 N=N PNP Osu 2-SHPY HOBI a. Rank the derivatives from most reactive (1) to least reactive (4) (under the structures above, or using the abbreviations) as carboxylic acid derivatives. Explain your reasoning briefly. b. What carboxylic acid derivative is more reactive than all of these derivatives? Explain your answer.
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